Chopra Amit, Marak Creticus, Alappan Narendrakumar, Shim Chang
Division of Pulmonary and Critical Care, Albany Medical Center, Albany, NY, USA.
Division of Pulmonary and Critical Care, National Jewish Health, Denver, CO, USA.
Case Rep Pulmonol. 2015;2015:794592. doi: 10.1155/2015/794592. Epub 2015 Jan 29.
Hepatitis C virus infection is the leading cause of chronic liver disease in the United States of America. Pegylated interferon α and ribavirin combination is the mainstay of treatment. Severe pulmonary toxicities are rarely reported. We report here a case of severe form of organizing pneumonia secondary to pegylated interferon α therapy presenting as acute respiratory failure. Patient has near complete recovery with withdrawal of pegylated interferon α and steroid therapy. We report this case to raise the awareness of this rare but potentially life-threatening pulmonary complication of pegylated interferon α therapy.
丙型肝炎病毒感染是美利坚合众国慢性肝病的主要病因。聚乙二醇化干扰素α与利巴韦林联合用药是主要的治疗方法。严重肺部毒性的报道很少。我们在此报告一例聚乙二醇化干扰素α治疗继发的严重型机化性肺炎,表现为急性呼吸衰竭。患者在停用聚乙二醇化干扰素α和类固醇治疗后几乎完全康复。我们报告此病例以提高对聚乙二醇化干扰素α治疗这种罕见但可能危及生命的肺部并发症的认识。