全氟辛酸诱导大鼠肝脏过氧化物酶体β-氧化、微粒体1-酰基甘油磷酸胆碱酰基转移酶和胞质长链酰基辅酶A水解酶的性别相关差异。
Sex-related difference in the inductions by perfluoro-octanoic acid of peroxisomal beta-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase in rat liver.
作者信息
Kawashima Y, Uy-Yu N, Kozuka H
机构信息
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
出版信息
Biochem J. 1989 Jul 15;261(2):595-600. doi: 10.1042/bj2610595.
Abstract
Inductions by perfluoro-octanoic acid (PFOA) of hepatomegaly, peroxisomal beta-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase were compared in liver between male and female rats. Marked inductions of these four parameters were seen concurrently in liver of male rats, whereas the inductions in liver of female rats were far less pronounced. The sex-related difference in the response of rat liver to PFOA was much more marked than that seen with p-chlorophenoxyisobutyric acid (clofibric acid) or 2,2'-(decamethylenedithio)diethanol (tiadenol). Hormonal manipulations revealed that this sex-related difference in the inductions is strongly dependent on sex hormones, namely that testosterone is necessary for the inductions, whereas oestradiol prevented the inductions by PFOA.
摘要
比较了全氟辛酸（PFOA）对雄性和雌性大鼠肝脏中肝肿大、过氧化物酶体β-氧化、微粒体1-酰基甘油磷酸胆碱酰基转移酶和胞质长链酰基辅酶A水解酶的诱导作用。在雄性大鼠肝脏中同时观察到这四个参数的显著诱导，而雌性大鼠肝脏中的诱导作用则远不那么明显。大鼠肝脏对PFOA反应的性别相关差异比用对氯苯氧异丁酸（氯贝酸）或2,2'-（十亚甲基二硫代）二乙醇（替阿地诺）时观察到的差异更为显著。激素处理表明，诱导作用中这种性别相关差异强烈依赖于性激素，即睾酮是诱导所必需的，而雌二醇可阻止PFOA的诱导作用。
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