[三例接受放化疗的肛门鳞状细胞癌病例]

[Three cases of anal squamous cell carcinoma treated with chemoradiotherapy].

作者信息

Someno Yasunori, Ishikawa Toshiaki, Iwata Noriko, Takahashi Hidenori, Kikuchi Akifumi, Okazaki Satoshi, Ishiguro Megumi, Kobayashi Hirotoshi, Iida Satoru, Uetake Hiroyuki, Sugihara Kenichi

机构信息

Dept. of Surgical Oncology, Tokyo Medical and Dental University Graduate School.

出版信息

Gan To Kagaku Ryoho. 2014 Nov;41(12):1855-7.

PMID:25731353

Abstract

We reviewed the clinical records of 3 patients with anal squamous cell carcinoma treated with chemoradiotherapy (CRT). Case 1: The patient was diagnosed with StageI (T1N0M0) and treated with cisplatin (CDDP)+5-FU+radiation. Chemotherapy was discontinued after the second course because of adverse effects. She achieved partial response(PR), and underwent a salvage surgery. Seven months after the surgery, she died from other comorbidities. Case 2: The patient was diagnosed with Stage I (T1N0M0) and treated with CDDP+5-FU+radiation. Chemotherapy was discontinued after the second course because of adverse effects. He achieved PR, and underwent a salvage surgery. Three years and 7 months after the surgery, he died from other comorbidities. Case 3: The patient was diagnosed with Stage IIIB (T4N1M0) and treated with MMC+S-1+radiation. Chemotherapy was discontinued after the first course because of adverse effects. She achieved complete response (CR) and is still surviving without cancer recurrence. We conclude that CRT is an effective treatment for anal squamous cell carcinoma.

摘要

我们回顾了3例接受放化疗（CRT）治疗的肛门鳞状细胞癌患者的临床记录。病例1：患者被诊断为I期（T1N0M0），接受顺铂（CDDP）+5-氟尿嘧啶+放疗。由于不良反应，化疗在第二个疗程后停止。她获得了部分缓解（PR），并接受了挽救性手术。手术后7个月，她死于其他合并症。病例2：患者被诊断为I期（T1N0M0），接受CDDP+5-氟尿嘧啶+放疗。由于不良反应，化疗在第二个疗程后停止。他获得了PR，并接受了挽救性手术。手术后3年7个月，他死于其他合并症。病例3：患者被诊断为IIIB期（T4N1M0），接受丝裂霉素+替吉奥+放疗。由于不良反应，化疗在第一个疗程后停止。她获得了完全缓解（CR），至今仍存活且无癌症复发。我们得出结论，放化疗是治疗肛门鳞状细胞癌的有效方法。