Allen Clint T, Conley Barbara, Sunwoo John B, Van Waes Carter
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland.
Cancer Diagnosis Program, National Cancer Institute, NIH, Bethesda, Maryland.
Clin Cancer Res. 2015 Mar 1;21(5):942-3. doi: 10.1158/1078-0432.CCR-14-2550.
In a study published in the May 1, 2001, issue of Clinical Cancer Research, Sunwoo and colleagues provided evidence for proteasome inhibition of NF-κB and tumorigenesis, supporting early-phase clinical trials in solid malignancies of the upper aerodigestive tract. Subsequent clinical studies uncovered a dichotomy of responses in patients with hematopoietic and solid malignancies, and the mechanisms of resistance.
在2001年5月1日发表于《临床癌症研究》的一项研究中,孙宇及其同事提供了蛋白酶体抑制核因子κB和肿瘤发生的证据,为上呼吸消化道实体恶性肿瘤的早期临床试验提供了支持。随后的临床研究发现了血液系统恶性肿瘤和实体恶性肿瘤患者反应的差异以及耐药机制。