磷脂酰肌醇蛋白聚糖-3的表达与儿童肝母细胞瘤高度相关：一项系统性分析。
Expression of glypican-3 is highly associated with pediatric hepatoblastoma: a systemic analysis.
作者信息
Xiong Xiao-Li, Qin Huan, Yan Su-Qi, Zhou Li-Shan, Chen Peng, Zhao Dong- Chi
机构信息
Dept. of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China E-mail :
出版信息
Asian Pac J Cancer Prev. 2015;16(3):1029-31. doi: 10.7314/apjcp.2015.16.3.1029.
OBJECTIVE
Glypican-3 (GPC3) is reported to be an oncofetal protein that is a useful diagnostic immunomarker for hepatoblastoma. However, the results are not inclusive. This study systemically investigated the association between expression of GPC3 and pediatric hepatoblastoma.
METHODS
Clinical studies evaluating the association were identified using a predefined search strategy. GPC3 immunohistochemistry was applied in the pathological diagnosis of hepatoblastoma using the monoclonal antibodies with formalin-fixed and paraffin-embedded specimens. Positive predictive rates for the association between expression of GPC3 and pediatric hepatoblastoma were calculated.
RESULTS
Specimens from four clinical studies which including 134 patients with pediatric hepatoblastoma tested by GPC3 immunohistochemistry were considered eligible for inclusion. Systemic analysis showed that, in all patients, pooled positive predictive rate of the association between expression of GPC3 and pediatric hepatoblastoma was 95.5% (128/134).
CONCLUSION
This systemic analysis suggests that the expression of glypican-3 is highly associated with the diagnosis of pediatric hepatoblastoma.
目的
据报道，磷脂酰肌醇蛋白聚糖-3（GPC3）是一种癌胚蛋白，是肝母细胞瘤有用的诊断免疫标志物。然而，结果并不具有全面性。本研究系统地调查了GPC3表达与小儿肝母细胞瘤之间的关联。
方法
使用预定义的搜索策略确定评估该关联的临床研究。采用单克隆抗体对福尔马林固定石蜡包埋标本进行GPC3免疫组织化学染色，用于肝母细胞瘤的病理诊断。计算GPC3表达与小儿肝母细胞瘤之间关联的阳性预测率。
结果
四项临床研究的标本符合纳入标准，这些标本包括134例接受GPC3免疫组织化学检测的小儿肝母细胞瘤患者。系统分析表明，在所有患者中，GPC3表达与小儿肝母细胞瘤之间关联的合并阳性预测率为95.5%（128/134）。
结论
该系统分析表明，磷脂酰肌醇蛋白聚糖-3的表达与小儿肝母细胞瘤的诊断高度相关。
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