烟草、酒精及吸烟习惯对经组织学证实为上皮发育异常的口腔癌前病变的影响。
Effect of tobacco, alcohol, and smoking habits in oral precancer with histological proven epithelial dysplasia.
作者信息
Nayak Seema, Chandra Saumya, Mehrotra Divya, Kumar Sumit, Agrawal S P, Kumar Sandeep, Goel Madhu Mati
机构信息
PhD Scholar, Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India.
Professor, Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow 226003, Uttar Pradesh, India.
出版信息
J Oral Biol Craniofac Res. 2012 Sep-Dec;2(3):159-62. doi: 10.1016/j.jobcr.2012.10.008. Epub 2012 Oct 24.
OBJECTIVES
To assess the effect of risk factors tobacco, alcohol, and smoking habits in oral precancer patients with epithelial dysplasia status.
MATERIAL AND METHODS
The study sample included biopsy proven cases of 29 oral submucous fibrosis (OSMF) and 43 cases of clinical leukoplakia. Histopathological diagnosis was made from formalin fixed paraffin embedded tissues as per WHO criteria. The relevant clinical and demographic details were recorded after interviewing the patients. Risk for tobacco, alcohol and smoking was determined by logistic regression analysis by SPSS software.
RESULTS
Presence of epithelial dysplasia was significantly associated with tobacco in OSMF & both tobacco and smoking habits in leukoplakia. In OSMF tobacco was associated with 14.16-fold (95% CI, 1.36-147.07; p < 0.026) and in leukoplakia tobacco was associated with 4.66-fold (95% CI, 1.00-21.63; p < 0.047) and smoking was associated with 9.20-fold (95% CI, 1.65-51.28; p < 0.011) increased risk of epithelial dysplasia.
CONCLUSION
Tobacco consumption was independent risk factor for epithelial dysplasia in OSMF and both tobacco and cigarette smoking were independent factors for epithelial dysplasia in leukoplakia.
目的
评估烟草、酒精和吸烟习惯等危险因素对口腔癌前病变患者上皮发育异常状态的影响。
材料与方法
研究样本包括经活检证实的29例口腔黏膜下纤维化（OSMF）病例和43例临床白斑病例。根据WHO标准，从福尔马林固定石蜡包埋组织中进行组织病理学诊断。在对患者进行访谈后记录相关的临床和人口统计学细节。通过SPSS软件进行逻辑回归分析来确定烟草、酒精和吸烟的风险。
结果
上皮发育异常的存在与OSMF中的烟草以及白斑中的烟草和吸烟习惯显著相关。在OSMF中，烟草与14.16倍（95%CI，1.36 - 147.07；p < 0.026）相关，在白斑中，烟草与4.66倍（95%CI，1.00 - 21.63；p < 0.047）相关，吸烟与9.20倍（95%CI，1.65 - 51.28；p < 0.011）的上皮发育异常风险增加相关。
结论
烟草消费是OSMF上皮发育异常的独立危险因素，烟草和吸烟都是白斑上皮发育异常的独立危险因素。
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