[神经源性膀胱过度活动症的当前药物治疗]
[Current pharmacotherapy of overactive bladder in neurological patients].
作者信息
Shvarts P G, Vinarov A Z, Kadykov A S, Borodulina I V, Popov S V, Kravchenko M A
机构信息
FGBU 'Nauchnyĭ tsentr nevrologii' RAMN, Moskva; Nauchno-issledovatel'skiĭ institut uronefrologii i reproduktivnogo zdorov'ia cheloveka, Moskva.
Nauchno-issledovatel'skiĭ institut uronefrologii i reproduktivnogo zdorov'ia cheloveka, Moskva; GBOU VPO 'Pervyĭ moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova', Moskva.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(12):152-160. doi: 10.17116/jnevro2014114121152-160.
The literature data on the urgent neurological problem - overactive bladder (OAB) are summarized. The OAB prevalence, current conceptions on the physiology and pathophysiology of urination and pathogenetic mechanisms of OAB development are presented. Main groups of pharmacological agents used in OAB treatment are described. Special attention is drawn to rationale of using anticholinergic (antimuscarinic) drugs. The authors present the results of their own comparative analysis on the efficacy and tolerability of these drugs in treatment of patients with cerebral vascular diseases including the use of solifenacin succinate (VESIcare).
总结了关于急迫性神经问题——膀胱过度活动症（OAB）的文献数据。介绍了OAB的患病率、目前关于排尿生理和病理生理的概念以及OAB发生的发病机制。描述了用于OAB治疗的主要药物类别。特别关注使用抗胆碱能（抗毒蕈碱）药物的基本原理。作者展示了他们自己对这些药物治疗脑血管疾病患者的疗效和耐受性的比较分析结果，包括琥珀酸索利那新（卫喜康）的使用。
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