Zogbi Luciano, Juliano Camila, Neutzling Aluísio
Department of Surgery, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil
Department of Pathology, Centro Integrado de Patologia - CIP, Rio Grande, RS, Brazil.
J Surg Case Rep. 2015 Mar 4;2015(3):rjv010. doi: 10.1093/jscr/rjv010.
Atypical fibroxanthoma (AFX) is a rare skin neoplasm of low-grade malignancy and fibroblastic origin. AFX is a curable cutaneous disease and the diagnosis depends on knowledge of its clinical and histological features and combined immunohistochemistry markers. This study presents a case of a male patient, aged 90 years, presented with painless skin lesion in his ear. The lesion had been growing progressively for 2 months, measured ∼1.5 cm, ulcerated, fixed and firm. After a biopsy, the patient underwent a complete resection with adequate surgical margins and showed favorable evolution without complications or recurrence. The histopathological evaluation showed a poorly circumscribed ulcerated dermal nodule, mesenchymal proliferation, with pleomorphic spindle cells. There was infiltration of the deep dermis and subcutis, showing malignant features, but there was no invasion of cartilage. The immunohistochemical analysis confirmed the diagnosis of AFX.
非典型纤维黄色瘤（AFX）是一种罕见的低度恶性皮肤肿瘤，起源于成纤维细胞。AFX是一种可治愈的皮肤疾病，其诊断依赖于对其临床和组织学特征以及联合免疫组化标志物的了解。本研究报告了一例90岁男性患者，其耳部出现无痛性皮肤病变。该病变逐渐增大2个月，大小约1.5 cm，有溃疡、固定且质地坚硬。活检后，患者接受了手术切缘充分的完整切除，术后病情进展良好，无并发症或复发。组织病理学评估显示为边界不清的溃疡型真皮结节，间质增生，可见多形性梭形细胞。深部真皮和皮下组织有浸润，呈现恶性特征，但未侵犯软骨。免疫组化分析证实了AFX的诊断。
