血清瘦素水平与骨密度之间的关系：一项系统评价和荟萃分析。
Relationship between serum leptin levels and bone mineral density: a systematic review and meta-analysis.
作者信息
Liu Kuan, Liu Pengcheng, Liu Run, Wu Xing, Cai Ming
机构信息
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
出版信息
Clin Chim Acta. 2015 Apr 15;444:260-3. doi: 10.1016/j.cca.2015.02.040. Epub 2015 Mar 4.
BACKGROUND
The association between leptin and bone mineral density (BMD) is controversial because of conflicting findings from previous studies.
METHODS
This meta-analysis aimed to provide an overview of the serum leptin levels and BMD in a healthy population. We reviewed the PubMed, Embase, and Cochrane Library databases until July 2014 for research on the association between leptin levels and BMD in healthy people.
RESULTS
We included and analyzed 45 studies in this systematic review and meta-analysis. The pooled correlations between leptin and BMD were analyzed by using the method of the inverse of the variance. Leptin was positively associated with BMD and the bone mineral content (BMC), especially in postmenopausal women (pooled r: 0.13-0.49). Overall, high serum leptin levels were associated with higher BMD levels.
CONCLUSIONS
This meta-analysis suggests that serum leptin levels are positively associated with BMD and BMC, especially in postmenopausal women.
背景
由于先前研究结果相互矛盾，瘦素与骨密度（BMD）之间的关联存在争议。
方法
本荟萃分析旨在概述健康人群的血清瘦素水平和骨密度。我们检索了截至2014年7月的PubMed、Embase和Cochrane图书馆数据库，以查找关于健康人群瘦素水平与骨密度之间关联的研究。
结果
我们在这项系统评价和荟萃分析中纳入并分析了45项研究。采用方差倒数法分析瘦素与骨密度之间的合并相关性。瘦素与骨密度和骨矿物质含量（BMC）呈正相关，尤其是在绝经后女性中（合并r：0.13 - 0.49）。总体而言，高血清瘦素水平与较高的骨密度水平相关。
结论
这项荟萃分析表明，血清瘦素水平与骨密度和骨矿物质含量呈正相关，尤其是在绝经后女性中。
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