Ma Xiaokun, Wang Qingzhu, Qin Guijun, Zhao Yanyan, Zhang Yinghui, Ma Xiaojun, Li Zhizhen, Wang Zhimin, Ren Gaofei, Bi Yufang, Wang Weiqing, Ning Guang
Department of Endocrinology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhonghua Gan Zang Bing Za Zhi. 2015 Jan;23(1):55-8. doi: 10.3760/cma.j.issn.1007-3418.2015.01.013.
To compare the predictive value of liver enzymes and alcohol consumption for determining risk of type 2 diabetes (T2DM).
A cross-sectional study was conducted in Zhengzhou with a total of 2, 693 men.Participants' height, weight, and histories of smoking and drinking were recorded. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and blood glucose, as well as related metabolic indexes were detected.
Moderate daily alcohol consumption (more than 35 g ethanol/week and less than 140 g ethanol/week) decreased the risk of type 2 diabetes (OR =0.376, 95% CI:0.306 -0.463, P less than 0.05) but increased risk for higher levels of GGT and ALT (OR GGT =3.012, 95% CI:2.357-3.849, Pless than 0.01; ORALT =1.473, 95% CI:1.043-2.081, Pless than 0.05). In joint analyses of alcohol consumption and liver enzymes, the group of nondrinkers/light drinkers (less than or equal to 35 g ethanol/week) in the fourth quartile of GGT levels had the highest risk for type 2 diabetes (OR =12.219, 95% CI:6.217-24.016, P less than 0.01). The relationship of ALT and daily alcohol consumption with the risk of type 2 diabetes was almost the same as that of GGT (nondrinkers/light drinkers in the fourth quartile of ALT levels (OR =5.357, 95% CI:3.070-9.350, P less than 0.0 1).
GGT, ALT and daily alcohol consumption were independently associated with risk of type 2 diabetes. Nondrinkers/light drinkers with the highest levels ofGGT orALT were at high risk of type 2 diabetes.
比较肝酶和饮酒量对2型糖尿病（T2DM）风险的预测价值。
在郑州开展了一项横断面研究，共纳入2693名男性。记录参与者的身高、体重、吸烟和饮酒史。检测丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、γ-谷氨酰转移酶（GGT）水平、血糖以及相关代谢指标。
每日适度饮酒（每周摄入乙醇超过35克且少于140克）可降低2型糖尿病风险（OR =0.376，95%CI：0.306 -0.463，P<0.05），但会增加GGT和ALT水平升高的风险（OR GGT =3.012，95%CI：2.357 -3.849，P<0.01；OR ALT =1.473，95%CI：1.043 -2.081，P<0.05）。在饮酒量和肝酶的联合分析中，GGT水平处于第四四分位数的不饮酒者/轻度饮酒者（每周乙醇摄入量小于或等于35克）患2型糖尿病的风险最高（OR =12.219，95%CI：6.217 -24.016，P<0.01）。ALT和每日饮酒量与2型糖尿病风险的关系与GGT几乎相同（ALT水平处于第四四分位数的不饮酒者/轻度饮酒者（OR =5.357，95%CI：3.070 -9.350，P<0.01）。
GGT、ALT和每日饮酒量与2型糖尿病风险独立相关。GGT或ALT水平最高的不饮酒者/轻度饮酒者患2型糖尿病的风险较高。
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