模拟阳光对恶性黑色素瘤患者朗格汉斯细胞的影响。
Effect of simulated sunlight on Langerhans' cells in malignant melanoma patients.
作者信息
Powles A V, Murphy G M, Rutman A J, Haffenden G, Rosin R D, Hawk J L, Fry L
机构信息
Department of Dermatology, St. Mary's Hospital, London, England.
出版信息
Acta Derm Venereol. 1989;69(6):482-6.
The effect of artificial sunlight on the number and HLA class II expression of Langerhans' cells was studied in 10 patients with malignant melanoma and 10 control volunteers. The total number of Langerhans' cell decreased in both groups but at 96 h there was a greater and significant decrease (p less than 0.01) in the number of Langerhans' cells in the melanoma group, compared with controls. This decrease persisted and was still greater in the melanoma group (p less than 0.02) at one week post-irradiation. There was a rise in Langerhans' cell count over the following 3 weeks in both groups. Unexpectedly, during this period in the melanoma group-but not controls-there was a significant median peak rise above pre-irradiation levels (p less than 0.001). Alteration in the response of Langerhans' cells to sunlight may play a part in the aetiology of malignant melanoma.
在10例恶性黑色素瘤患者和10名对照志愿者中研究了人工阳光对朗格汉斯细胞数量和HLA-II类表达的影响。两组朗格汉斯细胞总数均减少，但在96小时时，与对照组相比，黑色素瘤组朗格汉斯细胞数量减少更显著（p<0.01）。这种减少持续存在，在照射后一周时黑色素瘤组仍更明显（p<0.02）。两组在接下来的3周内朗格汉斯细胞计数均有所上升。出乎意料的是，在此期间，黑色素瘤组（而非对照组）朗格汉斯细胞计数中位数显著高于照射前水平（p<0.001）。朗格汉斯细胞对阳光反应的改变可能在恶性黑色素瘤的病因学中起作用。
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