Thorngkham Pornwalai, Paradee Nophawan, Niamlang Sumonman, Sirivat Anuvat
Conductivity and Electroactive Polymer Research Unit, The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, 10330, Thailand.
J Pharm Sci. 2015 May;104(5):1795-803. doi: 10.1002/jps.24414. Epub 2015 Mar 5.
Transdermal drug delivery is an alternative route to transport the drug into the blood system. This method has been continuously developed to overcome limitations and is now suitable for a wide variety of drug molecules. In this work, the influences of electric field and conductive polymer were investigated for developing a unique drug delivery system from double-centrifuged natural rubber (DCNR) matrix. Indomethacin (IN) was loaded into polycarbazole (PCz) as a conductive polymer drug host to promote the efficient transportation of the drug. The IN-loaded PCz was blended with DCNR to form a transdermal patch. The permeation of IN through the PCz/NR film and pig skin was carrried out by a modified Franz diffusion cell. The IN diffused from DCNR film by the diffusion controlled combined with erosion mechanism depending on the pore formation period. The drug permeation increased with decreasing cross-link ratio because of more accessible pathways for the drug permeation. Moreover, an electric field and the inclusion of PCz as the drug carrier dramatically improved the diffusion of the drug from the membrane by through the electrorepulsive force and electro-reduced PCz expansion. Thus, the PCz/DCNR films are shown here as a potential transdermal patch under applied electric field.
经皮给药是将药物输送到血液系统的一种替代途径。这种方法一直在不断发展以克服其局限性，现在适用于各种各样的药物分子。在这项工作中，研究了电场和导电聚合物对从双离心天然橡胶（DCNR）基质开发独特给药系统的影响。将吲哚美辛（IN）负载到作为导电聚合物药物载体的聚咔唑（PCz）中，以促进药物的有效运输。将负载IN的PCz与DCNR混合以形成透皮贴剂。通过改进的弗兰兹扩散池进行IN透过PCz/NR膜和猪皮的渗透实验。IN从DCNR膜扩散是通过扩散控制并结合取决于成孔期的侵蚀机制进行的。由于药物渗透的途径更多，药物渗透随着交联比的降低而增加。此外，电场和作为药物载体的PCz的加入通过电排斥力和电还原的PCz膨胀显著改善了药物从膜中的扩散。因此，在此展示了PCz/DCNR膜在施加电场下作为潜在透皮贴剂的特性。
