Bloch Sune Land, McKenna Michael John, Adams Joe, Friis Morten
Department of Otolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark
Massachusetts Eye & Ear Infirmary, Harvard University Medical School, Boston, MA, USA.
Ann Otol Rhinol Laryngol. 2015 Aug;124(8):649-54. doi: 10.1177/0003489415573960. Epub 2015 Mar 10.
It has been suggested that remodeling of the otic capsule is highly suppressed by the action of anti-resorptive signals emanating from structures of the inner ear space. Labyrinthitis ossificans (LO) is a severe complication to bacterial meningitis and is characterized by destruction of inner ear structures by the formation of new bone. The aim of this study was to explore the impact of LO on bone remodeling of the otic capsule.
In 11 human temporal bones with extensive LO and 10 control specimens, the degree of bone remodeling was explored indirectly by estimating the viability of osteocytes in perilabyrinthine bone and the mastoid.
The viability of osteocytes was significantly lower in the perilabyrinthine bone compared to the mastoid in both groups. However, the loss of perilabyrinthine osteocytes was the same in the 2 groups, and the presence of cartilage remnants appeared to be the same.
This study indicates that the factors affecting bone remodeling of the otic capsule and the degeneration of osteocytes are not altered by wholesale destruction of inner ear soft tissue and its replacement by bone. Therefore, alternative mechanisms may be implicated in the suppression of capsular bone remodeling.
有人提出，内耳空间结构发出的抗吸收信号的作用可高度抑制耳囊重塑。骨化性迷路炎（LO）是细菌性脑膜炎的一种严重并发症，其特征是内耳结构因新骨形成而遭到破坏。本研究的目的是探讨LO对耳囊骨重塑的影响。
在11例患有广泛LO的人类颞骨和10个对照标本中，通过评估迷路周围骨和乳突中骨细胞的活力间接探讨骨重塑程度。
两组中，迷路周围骨中骨细胞的活力均显著低于乳突。然而，两组迷路周围骨细胞的损失情况相同，软骨残余物的存在情况似乎也相同。
本研究表明，内耳软组织的全面破坏及其被骨替代并不会改变影响耳囊骨重塑的因素以及骨细胞的退变。因此，可能存在其他机制参与抑制囊状骨重塑。
