Wu Ze-Qian, Tan Lei, Liu Ting, Gao Zhi-Liang, Ke Wei-Min
Ze-Qian Wu, Zhi-Liang Gao, Wei-Min Ke, Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
World J Gastroenterol. 2015 Mar 7;21(9):2739-45. doi: 10.3748/wjg.v21.i9.2739.
To investigate the dynamic changes of serum hepatitis B surface antigen (HBsAg) levels apportioned by the same hepatic parenchyma cell volume (HPCV), namely, hepatic cell quantities.
Serum HBsAg levels were detected by electrochemiluminescence and serum HBsAg levels apportioned by the same HPCV were figured out according to the theory of sphere geometry. HBsAg levels were compared among different liver inflammation grades, as well as different hepatic fibrosis stages.
In hepatitis B e antigen-negative chronic hepatitis B, serum HBsAg levels in liver histological inflammation grades 1-4 were 3.66 ± 0.40, 3.74 ± 0.35, 3.74 ± 0.26 and 3.71 ± 0.34 log10 COI (cut off index), respectively, and there were no differences before apportion (P = 0.640). Serum HBsAg levels apportioned by the same HPCV were 5.57 ± 0.62, 5.98 ± 0.65, 6.59 ± 0.50 and 6.81 ± 0.84 log10 COI, respectively, and there were significant differences after apportion (P < 0.001). Serum HBsAg levels in hepatic fibrosis stages I-IV were 3.66 ± 0.43, 3.75 ± 0.33, 3.71 ± 0.28 and 3.75 ± 0.26 log10 COI, respectively, and there were no differences before apportion (P = 0.513). Serum HBsAg levels apportioned by the same HPCV were 5.53 ± 0.66, 5.98 ± 0.53, 6.29 ± 0.46 and 7.06 ± 0.48 log10 COI, respectively, and there were significant differences after apportion (P < 0.001).
Serum HBsAg levels apportioned by the same HPCV (hepatic cell quantities), rather than serum HBsAg levels, increase with liver inflammation grades and hepatic fibrosis stages.
研究按相同肝实质细胞体积（HPCV）即肝细胞数量分摊的血清乙型肝炎表面抗原（HBsAg）水平的动态变化。
采用电化学发光法检测血清HBsAg水平，并根据球体几何理论计算按相同HPCV分摊的血清HBsAg水平。比较不同肝脏炎症分级及不同肝纤维化分期的HBsAg水平。
在乙型肝炎e抗原阴性慢性乙型肝炎中，肝脏组织学炎症1 - 4级的血清HBsAg水平分别为3.66±0.40、3.74±0.35、3.74±0.26和3.71±0.34 log10 COI（临界指数），分摊前无差异（P = 0.640）。按相同HPCV分摊的血清HBsAg水平分别为5.57±0.62、5.98±0.65、6.59±0.50和6.81±0.84 log10 COI，分摊后有显著差异（P < 0.001）。肝纤维化I - IV期的血清HBsAg水平分别为3.66±0.43、3.75±0.33、3.71±0.28和3.75±0.26 log10 COI，分摊前无差异（P = 0.513）。按相同HPCV分摊的血清HBsAg水平分别为5.53±0.66、5.98±0.53、6.29±0.46和7.06±0.48 log10 COI，分摊后有显著差异（P < 0.001）。
按相同HPCV（肝细胞数量）分摊的血清HBsAg水平而非血清HBsAg水平随肝脏炎症分级和肝纤维化分期增加。
