轻度至中度痴呆老年个体直立性低血压的持续性及其预后意义
Persistence and Prognostic Implications of Orthostatic Hypotension in Older Individuals with Mild-to-Moderate Dementia.
作者信息
Soennesyn Hogne, Dalen Ingvild, Aarsland Dag
机构信息
Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
出版信息
Dement Geriatr Cogn Dis Extra. 2014 Jul 23;4(2):283-96. doi: 10.1159/000363514. eCollection 2014 May-Aug.
AIM
To study the course and prognostic implications of orthostatic hypotension (OH) in older individuals with mild-to-moderate dementia.
METHODS
Referrals to outpatient clinics specialising in old age psychiatry and geriatric medicine in the counties of Rogaland and Hordaland in western Norway with a first-time diagnosis of mild dementia were consecutively asked for inclusion. A total of 211 participants underwent a comprehensive baseline assessment with annual follow-ups. Patients with OH at both baseline and the 1-year follow-up were classified as having persistent OH. Outcome measures were the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating sum of boxes (CDR-SB), and time to death.
RESULTS
From baseline to the 4-year follow-up, 30-45% of the participants had OH at each follow-up. In multivariable analysis, persistent OH was not significantly associated with either the longitudinal course of MMSE or CDR-SB scores or survival.
CONCLUSIONS
OH was moderately prevalent over 4 years in older individuals with mild dementia, and persistent OH did not predict either cognitive or functional decline or survival.
目的
研究轻度至中度痴呆的老年人中体位性低血压（OH）的病程及预后影响。
方法
连续邀请挪威西部罗加兰郡和霍达兰郡首次诊断为轻度痴呆且转诊至老年精神病学和老年医学门诊的患者纳入研究。共有211名参与者接受了全面的基线评估，并进行年度随访。在基线和1年随访时均患有OH的患者被归类为持续性OH。结局指标为简易精神状态检查表（MMSE）、临床痴呆评定量表框和（CDR-SB）以及死亡时间。
结果
从基线到4年随访，每次随访时有30%-45%的参与者患有OH。在多变量分析中，持续性OH与MMSE或CDR-SB评分的纵向病程或生存率均无显著关联。
结论
在轻度痴呆的老年人中，OH在4年期间中度流行，持续性OH并不能预测认知或功能衰退或生存率。
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