Jayaweera Hirosha K, Hickie Ian B, Duffy Shantel L, Hermens Daniel F, Mowszowski Loren, Diamond Keri, Terpening Zoe, Paradise Matthew, Lewis Simon J G, Lagopoulos Jim, Naismith Sharon L
Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
J Geriatr Psychiatry Neurol. 2015 Sep;28(3):174-83. doi: 10.1177/0891988715573535. Epub 2015 Mar 10.
To examine the rates and clinical characteristics of mild cognitive impairment (MCI) in older people with depressive symptoms and to determine the relative contribution of hippocampal volume and MCI to memory change.
One hundred and fifty-two participants with lifetime Major Depression and remitted or mild symptoms and 28 healthy controls underwent psychiatric and neuropsychological assessments. Magnetic resonance imaging was also conducted in a subset of the patients (n = 81) and healthy controls (n = 18).
MCI was diagnosed in 75.7% of the patients and was associated with increasing age, medical burden, vascular risk factors, later age of depression onset and smaller hippocampi. Multiple regression showed that both hippocampal volume and MCI diagnosis mediate memory performance in depression.
MCI occurs in older adults with a history of depression and is not simply due to symptom severity. Memory change is linked to underlying hippocampal atrophy in this patient group.
研究有抑郁症状的老年人中轻度认知障碍（MCI）的发生率及临床特征，并确定海马体积和MCI对记忆变化的相对影响。
152名有终生重度抑郁且症状已缓解或为轻度症状的参与者以及28名健康对照者接受了精神和神经心理学评估。部分患者（n = 81）和健康对照者（n = 18）还进行了磁共振成像检查。
75.7%的患者被诊断为MCI，且与年龄增长、医疗负担、血管危险因素、抑郁发病较晚以及较小的海马体有关。多元回归分析表明，海马体积和MCI诊断均介导了抑郁症患者的记忆表现。
MCI发生于有抑郁症病史的老年人中，并非仅仅由于症状严重程度所致。在该患者群体中，记忆变化与潜在的海马萎缩有关。
