通过金催化共轭二炔的串联环化直接构建稠合吲哚。
Direct construction of fused indoles by gold-catalyzed cascade cyclization of conjugated diynes.
作者信息
Naoe Saori, Saito Tatsuo, Uchiyama Masanobu, Oishi Shinya, Fujii Nobutaka, Ohno Hiroaki
机构信息
†Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
‡Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Org Lett. 2015 Apr 3;17(7):1774-7. doi: 10.1021/acs.orglett.5b00550. Epub 2015 Mar 12.
A gold-catalyzed cascade cyclization of aniline derivatives bearing a conjugated diyne moiety was developed. Following the 5-endo-dig indole formation, subsequent 7-endo-dig cyclization predominated over 6-exo-dig cyclization to give the indole fused with a seven-membered ring in good yields.
开发了一种金催化的带有共轭二炔部分的苯胺衍生物的串联环化反应。在进行5-内型-双吲哚形成之后，随后的7-内型-双环化比6-外型-双环化更占优势，从而以良好的产率得到与七元环稠合的吲哚。
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