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1
STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.
Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):3985-90. doi: 10.1073/pnas.1503152112. Epub 2015 Mar 12.
4
Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity.
Oncogene. 2018 Jun;37(26):3589-3600. doi: 10.1038/s41388-018-0218-z. Epub 2018 Mar 26.
5
Epigenetic regulation of cell adhesion and communication by enhancer of zeste homolog 2 in human endothelial cells.
Hypertension. 2012 Nov;60(5):1176-83. doi: 10.1161/HYPERTENSIONAHA.112.191098. Epub 2012 Sep 10.
7
Methylation by EZH2 activates STAT3 in glioblastoma.
Cancer Discov. 2013 Jul;3(7):OF21. doi: 10.1158/2159-8290.CD-RW2013-112. Epub 2013 May 23.
8
Histone trimethylation of the p53 gene by expression of a constitutively active prolactin receptor in prostate cancer cells.
Chin J Physiol. 2013 Oct 31;56(5):282-90. doi: 10.4077/CJP.2013.BAB139. Epub 2013 Aug 31.
9
Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations.
Epigenomics. 2015 Aug;7(5):687-90. doi: 10.2217/epi.15.27. Epub 2015 Aug 28.
10
Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis.
Cell Rep. 2019 Nov 5;29(6):1482-1498.e4. doi: 10.1016/j.celrep.2019.10.004.

引用本文的文献

1
Case report: A special case of pneumonia with a novel STAT3 mutation and Talaromyces marneffei infection.
Respir Med Case Rep. 2025 Jul 30;57:102275. doi: 10.1016/j.rmcr.2025.102275. eCollection 2025.
4
Post translational modification regulation of transcription factors governing pancreatic β-cell identity and functional mass.
Front Endocrinol (Lausanne). 2025 Mar 11;16:1562646. doi: 10.3389/fendo.2025.1562646. eCollection 2025.
5
Exploring oncogenic roles and clinical significance of EZH2: focus on non-canonical activities.
Ther Adv Med Oncol. 2025 Jan 7;17:17588359241306026. doi: 10.1177/17588359241306026. eCollection 2025.
6
Targeting EZH2 in Cancer: Mechanisms, Pathways, and Therapeutic Potential.
Molecules. 2024 Dec 10;29(24):5817. doi: 10.3390/molecules29245817.
7
Lysine and arginine methylation of transcription factors.
Cell Mol Life Sci. 2024 Dec 16;82(1):5. doi: 10.1007/s00018-024-05531-6.
9
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis.
Curr Gene Ther. 2025;25(4):433-452. doi: 10.2174/0115665232336447241010094744.

本文引用的文献

1
Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3.
J Biol Chem. 2014 Oct 31;289(44):30763-30771. doi: 10.1074/jbc.M114.603894. Epub 2014 Sep 12.
2
STAT3: An Anti-Invasive Factor in Colorectal Cancer?
Cancers (Basel). 2014 Jul 3;6(3):1394-407. doi: 10.3390/cancers6031394.
3
Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.
Cancers (Basel). 2014 Apr 16;6(2):926-57. doi: 10.3390/cancers6020926.
4
Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis.
Cell Signal. 2014 Jul;26(7):1445-55. doi: 10.1016/j.cellsig.2014.03.007. Epub 2014 Mar 20.
5
EZH2: biology, disease, and structure-based drug discovery.
Acta Pharmacol Sin. 2014 Feb;35(2):161-74. doi: 10.1038/aps.2013.161. Epub 2013 Dec 23.
7
EZH2 in normal and malignant hematopoiesis.
Leukemia. 2014 Jan;28(1):44-9. doi: 10.1038/leu.2013.288. Epub 2013 Oct 7.
8
STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor.
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16975-80. doi: 10.1073/pnas.1315862110. Epub 2013 Sep 30.
9
STAT signaling in the pathogenesis and treatment of myeloid malignancies.
JAKSTAT. 2012 Apr 1;1(2):55-64. doi: 10.4161/jkst.20006.
10
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells.
Cancer Cell. 2013 Jun 10;23(6):839-52. doi: 10.1016/j.ccr.2013.04.008. Epub 2013 May 16.

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