1-二苯基乙酰胺-2-丁醇新衍生物的合成与药理性质
Synthesis and pharmacological properties of new derivatives of 1-diphenylacetamide-2-butanol.
作者信息
Kolasa K, Kleinrok Z, Pietrasiewicz T, Czechowska G, Zejc A, Gajewczyk L
机构信息
Department of Pharmacology, Medical Academy, Lublin.
出版信息
Pol J Pharmacol Pharm. 1989 Sep-Oct;41(5):475-81.
PMID:2577062
Abstract
Newly synthesized derivatives of 1-diphenylacetamide-2-butanol were investigated pharmacologically for their central properties in mice and rats. The most active were 2 compounds: racemic (RS) and enantiomer S (+) form of N-diphenylacetamide-2-butanol which produced hypothermia in normothermic mice, showed anxiolytic action in the four-plate test and reversed reserpine-induced hypothermia.
摘要
对新合成的1-二苯基乙酰胺-2-丁醇衍生物进行了药理学研究，以考察其对小鼠和大鼠的中枢作用。其中活性最强的是2种化合物：外消旋体（RS）和N-二苯基乙酰胺-2-丁醇的对映体S（+）形式，它们可使正常体温小鼠体温降低，在四板试验中表现出抗焦虑作用，并能逆转利血平引起的体温降低。
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