Chhun Virakpagna, Sacko Oumar, Boetto Sergio, Roux Franck-Emmanuel
Pôle Neuroscience (neurochirurgie), Centre hospitalo-universitaire de Toulouse, Université Paul-Sabatier, Toulouse, France.
Pôle Neuroscience (neurochirurgie), Centre hospitalo-universitaire de Toulouse, Université Paul-Sabatier, Toulouse, France.
World Neurosurg. 2015 Jun;83(6):970-5. doi: 10.1016/j.wneu.2015.01.058. Epub 2015 Mar 13.
Our objective was to analyze the relevance, potential prognostic factors, and complications of endoscopic third ventriculostomy (ETV) in patients with shunt failures.
Among 721 ETVs performed between 1999 and 2013, we studied 53 patients with shunts (31 men, 21 less than 18 years of age) who had an ETV performed for shunt failures as the result of various causes. We included all initial causes of hydrocephalus except adult chronic (i.e., "normal pressure") and pediatric communicant hydrocephalus. The mean duration between initial shunting for hydrocephalus and the ETV procedure was more than 11 years (137 months; range, 1 month to 34 years). Successful ETV procedure was defined as clinical improvement and shunt independence extending until the last follow-up visit.
The success rate of the ETV procedure was 70% (37 of the 53 cases) with a mean follow-up of 51 months (from 3 to 157 months) and was not related to the age of the patient (P = 0.922), to the cause of hydrocephalus (P = 0.622), or to the number of shunt failures (P = 0.459). We also found no statistical difference (P = 0.343) between patients whose shunt had been in place for less than 5 years and those shunted more than 5 years. The presence of an infected shunt was not predictive of ETV failure (P = 0.395). No significant intraoperative or postoperative complications were noted.
This study confirms that ETV should be considered as the first therapeutic option before shunt revision in cases of initial obstructive hydrocephalus.
我们的目的是分析内镜下第三脑室造瘘术(ETV)在分流失败患者中的相关性、潜在预后因素及并发症。
在1999年至2013年间进行的721例ETV手术中,我们研究了53例接受分流术的患者(31例男性,21例年龄小于18岁),这些患者因各种原因导致分流失败而接受了ETV手术。我们纳入了除成人慢性(即“正常压力”)和小儿交通性脑积水之外的所有脑积水初始病因。脑积水初次分流与ETV手术之间的平均间隔时间超过11年(137个月;范围为1个月至34年)。成功的ETV手术定义为临床改善且直至最后一次随访时无需分流。
ETV手术成功率为70%(53例中的37例),平均随访时间为51个月(3至157个月),且与患者年龄(P = 0.922)、脑积水病因(P = 0.622)或分流失败次数(P = 0.459)无关。我们还发现,分流放置时间少于5年的患者与分流超过5年的患者之间无统计学差异(P = 0.343)。分流感染的存在并不能预测ETV失败(P = 0.395)。未观察到明显的术中或术后并发症。
本研究证实,对于初始梗阻性脑积水病例,在进行分流修复之前,应将ETV视为首选治疗方案。