Department of Animal Science, University of California, One Shields Ave, Davis, CA 95616 USA.
J Anim Sci Biotechnol. 2015 Feb 12;6(1):8. doi: 10.1186/s40104-015-0001-8. eCollection 2015.
Developmental programming of the fetus has consequences for physiologic responses in the offspring as an adult and, more recently, is implicated in the expression of altered phenotypes of future generations. Some phenotypes, such as fertility, bone strength, and adiposity are highly relevant to food animal production and in utero factors that impinge on those traits are vital to understand. A key systemic regulatory hormone is growth hormone (GH), which has a developmental role in virtually all tissues and organs. This review catalogs the impact of GH on tissue programming and how perturbations early in development influence GH function.
胎儿的发育编程对其成年后的生理反应有影响,最近还涉及到后代表型改变的表达。一些表型,如生育能力、骨强度和肥胖,与食用动物生产密切相关,因此了解影响这些特征的宫内因素至关重要。一种关键的系统调节激素是生长激素(GH),它在几乎所有组织和器官中都有发育作用。本综述列举了 GH 对组织编程的影响,以及早期发育中的干扰如何影响 GH 的功能。