机器人甲状腺手术后使用罗哌卡因的前瞻性随机对照试验：对术后疼痛的影响
Prospective, randomized controlled trial on use of ropivacaine after robotic thyroid surgery: Effects on postoperative pain.
作者信息
Bae Dong Sik, Kim Su-Jin, Koo Do Hoon, Paek Se-Hyun, Kwon Hyungju, Chai Young Jun, Choi June Young, Lee Kyu Eun, Youn Yeo-Kyu
机构信息
Department of Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Department of Surgery, Seoul National University College of Medicine and Hospital, Cancer Research Institute, Division of Surgery, Thyroid Center, Seoul National University Cancer Hospital, Seoul, Korea.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E588-93. doi: 10.1002/hed.24045. Epub 2015 Jul 6.
BACKGROUND
We evaluated the effects of ropivacaine for pain relief after robotic thyroid surgery.
METHODS
One hundred eight patients scheduled for robotic thyroid surgery were randomized into ropivacaine (n = 54) or control (n = 54) groups. After surgery, 40 mL of 0.25% ropivacaine or 0.9% saline (control) was instilled into the skin flap. Postoperative pain intensity (visual analog scale [VAS]), analgesic requirements (fentanyl), and adverse events were assessed at 1, 2, 4, 8, 16, and 24 hours postoperatively.
RESULTS
One hundred three patients completed the study protocol. VAS scores were lower in the ropivacaine group than the control group (p = .010); however, VAS scores were not significantly different after 8 hours postoperatively. Total analgesic consumption was higher in controls than ropivacaine-treated patients (p = .01). Adverse events did not differ between the 2 groups.
CONCLUSION
Ropivacaine instillation after robotic thyroid surgery reduces acute postoperative pain and analgesic requirements without adverse events. © 2015 Wiley Periodicals, Inc. Head Neck 38: E-E, 2016.
背景
我们评估了罗哌卡因对机器人甲状腺手术后疼痛缓解的效果。
方法
108例计划接受机器人甲状腺手术的患者被随机分为罗哌卡因组（n = 54）和对照组（n = 54）。手术后，将40毫升0.25%罗哌卡因或0.9%生理盐水（对照组）注入皮瓣。在术后1、2、4、8、16和24小时评估术后疼痛强度（视觉模拟评分法[VAS]）、镇痛需求（芬太尼）和不良事件。
结果
103例患者完成了研究方案。罗哌卡因组的VAS评分低于对照组（p = 0.010）；然而，术后8小时后VAS评分无显著差异。对照组的总镇痛药物消耗量高于罗哌卡因治疗的患者（p = 0.01）。两组之间的不良事件无差异。
结论
机器人甲状腺手术后注入罗哌卡因可减轻术后急性疼痛和镇痛需求，且无不良事件。©2015威利期刊公司。头颈外科38：E - E，2016。
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