胎儿血红蛋白遗传性持续存在的Gγβ+型中Aγ珠蛋白基因的序列。
The sequence of the A gamma globin gene in a G gamma beta+ type of hereditary persistence of fetal haemoglobin.
作者信息
Jones R W, Goodbourn S E, Old J M, Weatherall D J
出版信息
Br J Haematol. 1985 Feb;59(2):357-62. doi: 10.1111/j.1365-2141.1985.tb03000.x.
Abstract
The sequence of the A gamma globin gene from the affected chromosome of an individual heterozygous for the G gamma beta+ type of hereditary persistence of fetal haemoglobin (G gamma beta+ HPFH) is reported. With two exceptions, it is identical to one of the two allelic A gamma globin genes already sequenced and there is therefore no change which could explain the absence of its expression in the face of the persistent G gamma globin expression which is a feature of this condition.
摘要
报道了一名胎儿血红蛋白遗传性持续存在（Gγβ⁺ HPFH）的Gγβ⁺型杂合个体受影响染色体上的Aγ珠蛋白基因序列。除了两个例外，它与已测序的两个等位基因Aγ珠蛋白基因之一相同，因此不存在能够解释在这种情况下持续表达的Gγ珠蛋白存在时该基因却不表达的变化。
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