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足月儿母亲超重和肥胖的围产期结局:加拿大一项基于人群的队列研究

Perinatal outcomes of maternal overweight and obesity in term infants: a population-based cohort study in Canada.

作者信息

Vinturache Angela Elena, McDonald Sheila, Slater Donna, Tough Suzanne

机构信息

1] Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada [2] Department of Physiology &Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada [3] Alberta Children's Hospital Research Institute for Child and Maternal Health (ACHRI), Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.

1] Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada [2] Alberta Children's Hospital Research Institute for Child and Maternal Health (ACHRI), Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.

出版信息

Sci Rep. 2015 Mar 20;5:9334. doi: 10.1038/srep09334.

Abstract

The objective of this study was to assess the impact of increased pre-pregnancy maternal body mass index (BMI) on perinatal outcomes in term, singleton pregnancies who received prenatal care in community-based practices. The sample of 1996 infants included in the study was drawn from the All Our Babies Study, a prospective pregnancy cohort from Calgary. Multivariable logistic regression explored the relationship between the main outcomes, infant birth weight, Apgar score, admission to neonatal intensive care (NICU) and newborn duration of hospitalization, and BMI prior to pregnancy. Approximately 10% of the infants were macrosoms, 1.5% had a low Apgar score (<7 at 5 min), 6% were admitted to intensive care and 96% were discharged within 48 h after delivery. Although the infants of overweight and obese women were more likely to have increased birth weight as compared to infants of normal weight women, there were no differences in Apgar score, admission to NICU, or length of postnatal hospital stay among groups. This study suggests that in otherwise healthy term, singleton pregnancies, obesity does not seem to increase the risk of severe fetal impairment, neonatal admission to intensive care or duration of postnatal hospitalization.

摘要

本研究的目的是评估孕前孕妇体重指数(BMI)增加对在社区医疗机构接受产前护理的足月单胎妊娠围产期结局的影响。本研究纳入的1996例婴儿样本来自“我们所有的婴儿研究”,这是一项来自卡尔加里的前瞻性妊娠队列研究。多变量逻辑回归分析探讨了主要结局、婴儿出生体重、阿氏评分、入住新生儿重症监护病房(NICU)以及新生儿住院时长与孕前BMI之间的关系。约10%的婴儿为巨大儿,1.5%的婴儿阿氏评分低(5分钟时<7分),6%的婴儿入住重症监护病房,96%的婴儿在分娩后48小时内出院。尽管与体重正常的女性所生婴儿相比,超重和肥胖女性所生婴儿出生体重更有可能增加,但各组之间在阿氏评分、入住NICU或产后住院时长方面并无差异。本研究表明,在其他方面健康的足月单胎妊娠中,肥胖似乎不会增加严重胎儿损伤、新生儿入住重症监护病房或产后住院时长的风险。

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