Shin Jaehoon, Ming Guo-Li, Song Hongjun
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Mol Cell. 2015 Mar 19;57(6):949-950. doi: 10.1016/j.molcel.2015.03.007.
In this issue of Molecular Cell, Laurent et al. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.
在本期《分子细胞》杂志中，洛朗等人（2015年）证明，含SVIL的复合物中一种神经元富集的LSD1亚型（LSD1+8a）具有H3K9me1/2特异性去甲基化活性。这种活性对哺乳动物神经发生过程中的基因激活至关重要。
