Van Dromme Ilse C L, Vanduffel Wim, Janssen Peter
Laboratorium voor Neuro-en Psychofysiologie, KU Leuven, Belgium.
Laboratorium voor Neuro-en Psychofysiologie, KU Leuven, Belgium; Athinoula A Martinos Ctr. Biomed Imaging, MGH, Charlestown, MA, USA; Radiology, Harvard Univ., Med. Sch., Boston, MA, USA.
Neuroimage. 2015 Jun;113:86-100. doi: 10.1016/j.neuroimage.2015.03.023. Epub 2015 Mar 18.
Previous functional magnetic resonance (fMRI) studies in humans and monkeys have demonstrated that the anterior intraparietal sulcus (IPS) is sensitive to the depth structure defined by binocular disparity. However, in the macaque monkey, a single large activation was measured in the anterior lateral bank of the IPS, whereas in human subjects two separate regions were sensitive to depth structure from disparity. We performed fMRI and single-cell experiments in the same animals, in a large number of recording sites in the lateral bank of the IPS. The fMRI interaction effect between the factors curvature (curved or flat) and disparity (stereo or control) correctly predicted the location of higher-order disparity selective neurons that encoded the depth structure of objects. However the large region in the IPS activated by depth structure consisted of two patches of higher-order disparity-selective neurons, one in the anterior IPS and one located more posteriorly, surrounded by regions lacking such selectivity. Thus the IPS region activated by curved surfaces consists of at least two patches of higher-order disparity selective neurons, which may reconcile previous fMRI studies in monkeys and humans.
以往对人类和猴子进行的功能磁共振成像（fMRI）研究表明，顶内沟前部（IPS）对双眼视差所定义的深度结构敏感。然而，在猕猴中，在IPS前外侧壁测量到一个单一的大激活区，而在人类受试者中，有两个独立区域对视差深度结构敏感。我们在同一批动物的IPS外侧壁的大量记录位点上进行了fMRI和单细胞实验。曲率（弯曲或平坦）和视差（立体或对照）因素之间的fMRI相互作用效应正确地预测了编码物体深度结构的高阶视差选择性神经元的位置。然而，由深度结构激活的IPS中的大区域由两片高阶视差选择性神经元组成，一片在前部IPS，另一片位于更靠后的位置，周围是缺乏这种选择性的区域。因此，由曲面激活的IPS区域至少由两片高阶视差选择性神经元组成，这可能调和了先前对猴子和人类的fMRI研究结果。
