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孕期罕见的抗N-甲基-D-天冬氨酸受体脑炎病例。

A rare case of anti-N-methyl-D-aspartate receptor encephalitis during pregnancy.

作者信息

Chan Lai Wan, Nilsson Christer, Schepel Jan, Lynch Christopher

机构信息

Department of Neurology, Waikato Hospital, Corner Selwyn and Pembroke Street, 3204 Hamilton, New Zealand.

出版信息

N Z Med J. 2015 Mar 27;128(1411):89-91.

Abstract

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis was first described as a severe form of encephalitis by Dalmau et al in 2006. This is an autoimmune disorder usually associated with paraneoplastic mechanism that manifests as neuropsychiatric disorder affecting mainly women of child-bearing age. Nevertheless anti- NMDA receptor encephalitis is a rare condition during pregnancy. To -date, there have been only four reported cases during pregnancy. We report a case of a 23-year-old primigravida in first trimester pregnancy with altered mental status and multiple neurological symptoms related to anti-NMDA receptor encephalitis. To the best of our knowledge, this is the first reported anti-NMDA receptor encephalitis during pregnancy in Australasia.

摘要

抗N-甲基-D-天冬氨酸(NMDA)受体脑炎于2006年由达尔毛等人首次描述为一种严重的脑炎形式。这是一种通常与副肿瘤机制相关的自身免疫性疾病,表现为主要影响育龄妇女的神经精神障碍。然而,抗NMDA受体脑炎在妊娠期间是一种罕见的病症。迄今为止,妊娠期间仅报告过4例病例。我们报告一例23岁初产妇,孕早期出现精神状态改变及与抗NMDA受体脑炎相关的多种神经症状。据我们所知,这是大洋洲地区首次报告的妊娠期间抗NMDA受体脑炎病例。

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