Chan Lai Wan, Nilsson Christer, Schepel Jan, Lynch Christopher
Department of Neurology, Waikato Hospital, Corner Selwyn and Pembroke Street, 3204 Hamilton, New Zealand.
N Z Med J. 2015 Mar 27;128(1411):89-91.
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis was first described as a severe form of encephalitis by Dalmau et al in 2006. This is an autoimmune disorder usually associated with paraneoplastic mechanism that manifests as neuropsychiatric disorder affecting mainly women of child-bearing age. Nevertheless anti- NMDA receptor encephalitis is a rare condition during pregnancy. To -date, there have been only four reported cases during pregnancy. We report a case of a 23-year-old primigravida in first trimester pregnancy with altered mental status and multiple neurological symptoms related to anti-NMDA receptor encephalitis. To the best of our knowledge, this is the first reported anti-NMDA receptor encephalitis during pregnancy in Australasia.
抗N-甲基-D-天冬氨酸（NMDA）受体脑炎于2006年由达尔毛等人首次描述为一种严重的脑炎形式。这是一种通常与副肿瘤机制相关的自身免疫性疾病，表现为主要影响育龄妇女的神经精神障碍。然而，抗NMDA受体脑炎在妊娠期间是一种罕见的病症。迄今为止，妊娠期间仅报告过4例病例。我们报告一例23岁初产妇，孕早期出现精神状态改变及与抗NMDA受体脑炎相关的多种神经症状。据我们所知，这是大洋洲地区首次报告的妊娠期间抗NMDA受体脑炎病例。
