草药疗法抑制高迁移率族蛋白B1分泌或作用的新机制。
Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action.
作者信息
Wu Andrew H, He Li, Long Wei, Zhou Qiuping, Zhu Shu, Wang Ping, Fan Saijun, Wang Haichao
机构信息
Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY 11030, USA ; The Feinstein Institute for Medical Research, North Shore-LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA.
Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Evid Based Complement Alternat Med. 2015;2015:456305. doi: 10.1155/2015/456305. Epub 2015 Mar 2.
High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here we review the distinct mechanisms by which several herbal components inhibit HMGB1 action or secretion, such as by modulating inflammasome activation, autophagic degradation, or endocytic uptake. In light of the reciprocal interactions between these cellular processes, it is possible to develop more effective combinational herbal therapies for the clinical management of inflammatory diseases.
高迁移率族蛋白B1（HMGB1）是一种进化上保守的蛋白质，几乎在所有类型的细胞中都有组成性表达。在应对微生物感染时，HMGB1从活化的免疫细胞中分泌出来，以协调严格的炎症反应。在这里，我们综述了几种草药成分抑制HMGB1作用或分泌的不同机制，例如通过调节炎性小体激活、自噬降解或内吞摄取。鉴于这些细胞过程之间的相互作用，有可能开发出更有效的联合草药疗法用于炎症性疾病的临床管理。
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