甘氨酰胺可预防精神分裂症阳性和认知症状动物模型中MK-801诱导的多动及物体识别记忆缺陷。 - Suppr

Glycinamide prevents MK-801-induced hyperactivity and deficits in object recognition memory in an animal model of positive and cognitive symptoms of schizophrenia.

作者信息

Basurto Enrique, Flores Oscar González, Hoffman Kurt Leroy

机构信息

Centro de Investigación en Reproducción Animal (CIRA), Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, Tlax., México.

出版信息

Schizophr Res. 2015 Aug;166(1-3):349-50. doi: 10.1016/j.schres.2015.02.024. Epub 2015 Mar 29.

DOI:10.1016/j.schres.2015.02.024

PMID:25823398

Abstract

摘要

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Glycinamide prevents MK-801-induced hyperactivity and deficits in object recognition memory in an animal model of positive and cognitive symptoms of schizophrenia.甘氨酰胺可预防精神分裂症阳性和认知症状动物模型中MK-801诱导的多动及物体识别记忆缺陷。

Schizophr Res. 2015 Aug;166(1-3):349-50. doi: 10.1016/j.schres.2015.02.024. Epub 2015 Mar 29.

Clozapine and glycinamide prevent MK-801-induced deficits in the novel object recognition (NOR) test in the domestic rabbit (Oryctolagus cuniculus).氯氮平和甘氨酰胺可预防MK-801诱导的家兔（穴兔）新物体识别（NOR）试验中的缺陷。

Behav Brain Res. 2014 Sep 1;271:203-11. doi: 10.1016/j.bbr.2014.06.012. Epub 2014 Jun 13.

D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats.D-丝氨酸和一种甘氨酸转运体抑制剂可改善MK-801诱导的大鼠新物体识别试验中的认知缺陷。

Behav Brain Res. 2008 Jan 10;186(1):78-83. doi: 10.1016/j.bbr.2007.07.033. Epub 2007 Aug 2.

Predictive validity of a MK-801-induced cognitive impairment model in mice: implications on the potential limitations and challenges of modeling cognitive impairment associated with schizophrenia preclinically.MK-801 诱导的认知障碍模型在小鼠中的预测效度：对临床前模拟精神分裂症相关认知障碍的潜在局限性和挑战的影响。

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:53-62. doi: 10.1016/j.pnpbp.2013.11.008. Epub 2013 Nov 19.

Effects of chronic prenatal MK-801 treatment on object recognition, cognitive flexibility, and drug-induced locomotor activity in juvenile and adult rat offspring.孕期慢性给予MK-801对幼年和成年大鼠子代物体识别、认知灵活性及药物诱导的运动活动的影响。

Behav Brain Res. 2017 Jun 15;328:62-69. doi: 10.1016/j.bbr.2017.04.004. Epub 2017 Apr 6.

Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia.SSR103800的特性研究，它是甘氨酸转运体-1的选择性抑制剂，用于在精神分裂症治疗活性预测模型中的研究。

Pharmacol Biochem Behav. 2008 Nov;91(1):47-58. doi: 10.1016/j.pbb.2008.06.009. Epub 2008 Jun 24.

SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.SSR180711，一种新型选择性α7烟碱受体部分激动剂：（II）在预测对精神分裂症认知症状有活性的实验模型中的疗效

Neuropsychopharmacology. 2007 Jan;32(1):17-34. doi: 10.1038/sj.npp.1301188. Epub 2006 Aug 23.

The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801.CB1受体配体对MK-801诱导的小鼠精神分裂症样效应的影响。

Neurotox Res. 2016 Nov;30(4):658-676. doi: 10.1007/s12640-016-9662-0. Epub 2016 Aug 30.

Memantine improves memory impairment and depressive-like behavior induced by amphetamine withdrawal in rats.美金刚可改善大鼠苯丙胺戒断所致的记忆损伤及类抑郁行为。

Brain Res. 2016 Jul 1;1642:389-396. doi: 10.1016/j.brainres.2016.04.026. Epub 2016 Apr 13.

Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia.多奈哌齐和α-7激动剂PHA 568487可改善精神分裂症认知障碍亚慢性MK-801小鼠模型中的空间记忆缺陷，而利培酮则不能。

Behav Brain Res. 2014 Oct 1;272:248-51. doi: 10.1016/j.bbr.2014.07.017. Epub 2014 Jul 15.

引用本文的文献

Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity.槲皮素可降低皮质 GABA 能传递并缓解 MK-801 诱导的过度兴奋。

EBioMedicine. 2018 Aug;34:201-213. doi: 10.1016/j.ebiom.2018.07.031. Epub 2018 Jul 26.

Cannabidiol Affects MK-801-Induced Changes in the PPI Learned Response of Capuchin Monkeys ( spp.).大麻二酚影响MK-801诱导的卷尾猴（僧面猴属）预脉冲抑制习得反应的变化。

Front Pharmacol. 2017 Feb 27;8:93. doi: 10.3389/fphar.2017.00093. eCollection 2017.

Sensorimotor gating impairments induced by MK-801 treatment may be reduced by tolerance effect and by familiarization in monkeys.由MK-801治疗引起的感觉运动门控障碍可能会因耐受效应和猴子的熟悉过程而减轻。

Front Pharmacol. 2015 Sep 22;6:204. doi: 10.3389/fphar.2015.00204. eCollection 2015.

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Glycinamide prevents MK-801-induced hyperactivity and deficits in object recognition memory in an animal model of positive and cognitive symptoms of schizophrenia.

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