Macpherson A M, Rogers P A, Beaton L A
Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Clayton, Victoria, Australia.
Cell Tissue Res. 1989 Nov;258(2):417-23. doi: 10.1007/BF00239463.
Pre-implantation-stage embryos from rats, mice, and guinea-pigs were transferred to a non-uterine site--the anterior chamber of the eye--of female recipients. All 9 combinations of transfers were performed: 3 allogeneic (intraspecies) transfers as controls, and 6 xenogeneic (interspecies) transfers. Implantation, as judged by extravasation from blood vessels of the iris or ciliary body occurred with success rates of 90.4% per transfer in the control rat group. 76.9% in the control mouse group, and 81.8% in the control guinea-pig group. Significantly reduced implantation rates occurred in the rat to guinea-pig (0%), mouse to rat (46.9%), mouse to guinea-pig (6.7%), and guinea-pig to rat (0%) groups compared to controls. Reductions, although not significant, also occurred in the other 2 groups: rat to mouse (77.8%), and guinea-pig to mouse (44.4%). These results together with some ultrastructural and light-microscopical observations suggest a degree of species specificity involved in the vascular response to the implanting embryo. We propose that the peri-implantation embryo produces a signal(s) which is to some extent species specific and which in the normal allogeneic situation is responsible for the early vascular effects seen at implantation in most eutherian mammals.
将大鼠、小鼠和豚鼠植入前阶段的胚胎移植到雌性受体的非子宫部位——眼前房。进行了所有9种移植组合：3种同种异体（种内）移植作为对照，6种异种（种间）移植。通过虹膜或睫状体血管外渗判断的着床情况，在对照大鼠组每次移植的成功率为90.4%，对照小鼠组为76.9%，对照豚鼠组为81.8%。与对照组相比，大鼠到豚鼠组（0%）、小鼠到大鼠组（46.9%）、小鼠到豚鼠组（6.7%）以及豚鼠到大鼠组（0%）的着床率显著降低。另外两组，大鼠到小鼠组（77.8%）和豚鼠到小鼠组（44.4%），着床率虽有降低，但不显著。这些结果连同一些超微结构和光学显微镜观察结果表明，血管对植入胚胎的反应存在一定程度的物种特异性。我们提出，着床前胚胎产生一种信号，这种信号在一定程度上具有物种特异性，在正常同种异体情况下，它是大多数真兽类哺乳动物着床时早期血管效应的原因。
