Skau Jutta K H, Touch Bunthang, Chhoun Chamnan, Chea Mary, Unni Uma S, Makurat Jan, Filteau Suzanne, Wieringa Frank T, Dijkhuizen Marjoleine A, Ritz Christian, Wells Jonathan C, Berger Jacques, Friis Henrik, Michaelsen Kim F, Roos Nanna
From the Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark (JKHS, MD, CR, HF, KFM, and NR); Inland Fisheries Research and Development Institute, Phnom Penh, Cambodia (BT); Department of Fisheries Post-harvest Technologies and Quality Control, Fishery Administration, Ministry of Agriculture, Forestry and Fisheries, Phnom Penh, Cambodia (CC); National Nutrition Programme, Maternal and Child Health Centre, Ministry of Health, Phnom Penh, Cambodia (MC); Institute of Nutritional Sciences, Justus Liebig University, Giessen, Germany (JM); Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom (SF); Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JW); St. John's Research Institute, Bangalore, India (USU); and Institut de Recherche pour le Développement (IRD), Montpellier, France (FW and JB).
Am J Clin Nutr. 2015 Apr;101(4):742-51. doi: 10.3945/ajcn.114.084889. Epub 2015 Jan 28.
Poor nutritional quality of complementary foods often limits growth. Animal source foods, such as milk or meat, are often unaffordable. Local affordable alternatives are needed.
We evaluate the efficacy of 2 newly developed, rice-based complementary food products: WinFood (WF) with small fish and edible spiders and WinFood-Lite (WF-L) fortified with small fish, against 2 existing fortified corn-soy blend products, CSB+ (purely plant based) and CSB++ (8% dried skimmed milk).
In total, 419 infants aged 6 mo were enrolled in this randomized, single-blinded study for 9 mo, designed primarily to assess increments in fat-free mass by a deuterium dilution technique and change in plasma ferritin and soluble transferrin receptor. Secondary endpoints were changes in anthropometric variables, including knee-heel length. Data were analyzed by the intention-to-treat approach.
There was no difference in fat-free mass increment in WF or WF-L compared with CSB+ [WF: +0.04 kg (95% CI: -0.20, 0.28 kg); WF-L: +0.14 kg (95% CI: -0.10, 0.38 kg)] or CSB++ [WF: -0.03 kg (95% CI: -0.27, 0.21 kg); WF-L: +0.07 kg (95% CI: -0.18, 0.31 kg)] and no effect on iron status. The 1.7-mm (95% CI: -0.1, 3.5 mm) greater increase in knee-heel length in WF-L than in CSB+ was not significant.
No difference was found between the locally produced products (WF and WF-L) and the CSBs. Micronutrient fortification may be necessary, and small fish may be an affordable alternative to milk to improve complementary foods. The dietary role of edible spiders needs to be further explored. This trial was registered at controlled-trials.com as ISRCTN19918531.
辅食的营养质量差常常限制生长发育。动物源食物，如牛奶或肉类，往往价格昂贵。因此需要当地可负担得起的替代食物。
我们评估两种新开发的以大米为基础的辅食产品的功效：添加小鱼和可食用蜘蛛的WinFood（WF）以及添加小鱼的WinFood-Lite（WF-L），并与两种现有的强化玉米-大豆混合产品CSB+（纯植物基）和CSB++（8%脱脂奶粉）进行比较。
总共419名6个月大的婴儿参与了这项随机单盲研究，为期9个月，主要目的是通过氘稀释技术评估去脂体重的增加以及血浆铁蛋白和可溶性转铁蛋白受体的变化。次要终点是人体测量变量的变化，包括膝跟长度。采用意向性分析方法对数据进行分析。
与CSB+相比，WF或WF-L的去脂体重增加量无差异[WF：+0.04千克（95%CI：-0.20，0.28千克）；WF-L：+0.14千克（95%CI：-0.10，0.38千克）]，与CSB++相比也无差异[WF：-0.03千克（95%CI：-0.27，0.21千克）；WF-L：+0.07千克（95%CI：-0.18，0.31千克）]，且对铁状态无影响。WF-L的膝跟长度比CSB+增加了1.7毫米（95%CI：-0.1，3.5毫米），但差异不显著。
当地生产的产品（WF和WF-L）与CSB之间未发现差异。可能需要进行微量营养素强化，小鱼可能是一种可负担得起的替代牛奶的食物，以改善辅食。可食用蜘蛛的饮食作用有待进一步探索。该试验已在controlled-trials.com上注册，注册号为ISRCTN19918531。
