Muir J L, Pfister H P
Department of Psychology, University of Newcastle, N.S.W. Australia.
Int J Neurosci. 1989 Oct;48(3-4):191-203. doi: 10.3109/00207458909002161.
The aim of these experiments was to investigate the effects of psychological stress and oxytocin treatment on levels of norepinephrine, dopamine and serotonin in the hypothalamus, hippocampus, striatum, midbrain and brainstem of lactating females. Stress and oxytocin treatment were applied during the third trimester of pregnancy, and females examined on day 6 and day 21 postpartum. The results indicated that serotonin levels were significantly increased on day 6 following unpredictable novelty stress during pregnancy. Furthermore, a marked reduction in serotonin levels in the hypothalamus, hippocampus, midbrain and brainstem was observed as a result of oxytocin treatment on both Day 6 and Day 21 postpartum. These results are in stark contrast to those obtained for nulliparous females in a previous study and suggest an important distinction between nulliparous and lactating females with respect to the effects of psychological stress and oxytocin treatment on central monoamine levels.
这些实验的目的是研究心理应激和催产素治疗对哺乳期雌性动物下丘脑、海马体、纹状体、中脑和脑干中去甲肾上腺素、多巴胺和血清素水平的影响。在妊娠晚期施加应激和催产素治疗，并在产后第6天和第21天对雌性动物进行检查。结果表明，孕期不可预测的新奇应激后第6天，血清素水平显著升高。此外，在产后第6天和第21天，由于催产素治疗，观察到下丘脑、海马体、中脑和脑干中的血清素水平显著降低。这些结果与之前一项研究中未生育雌性动物的结果形成鲜明对比，表明在心理应激和催产素治疗对中枢单胺水平的影响方面，未生育雌性动物和哺乳期雌性动物之间存在重要差异。
