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大踝关节手术后联合使用隐神经和坐骨神经导管镇痛:一项双盲随机对照试验

Combined saphenous and sciatic catheters for analgesia after major ankle surgery: a double-blinded randomized controlled trial.

作者信息

Fisker Anne K, Iversen Bo N, Christensen Steffen, Linde Frank, Nielsen Kristian K, Børglum Jens, Bendtsen Thomas F

机构信息

Department of Anesthesia, Aarhus University Hospital, Norrebrogade 44, 8000, Aarhus C, Denmark.

出版信息

Can J Anaesth. 2015 Aug;62(8):875-82. doi: 10.1007/s12630-015-0379-y. Epub 2015 Apr 8.

Abstract

PURPOSE

Continuous sciatic nerve block is used for pain management following major ankle surgery. Pain from the saphenous nerve territory often persists. We conducted a double-blinded randomized placebo-controlled trial to evaluate the effect of a supplementary saphenous catheter in the proximal thigh combined with a popliteal sciatic catheter and single-shot saphenous nerve block after major ankle surgery.

METHODS

Fifty patients received both sciatic and saphenous continuous catheters inserted along the short axis of the nerves with ultrasound-guidance. All patients had an initial sciatic nerve block followed by a continuous sciatic catheter infusion and an initial saphenous nerve block with ropivacaine. Participants were then randomized to infusion of either ropivacaine or isotonic saline in the saphenous catheter for 48 hr postoperatively. The primary outcome was total intravenous morphine consumption during the first 48 hr postoperatively. Secondary outcomes were clinical analgesia, saphenous analgesia, territory of worst pain, and patient satisfaction.

RESULTS

Forty-four patients were included in the analysis. The mean (SD) 48-hr morphine consumption was 24.7 (21.6) mg in the intervention group and 27.8 (20.1) mg in the placebo group (P = 0.63). The mean difference in 48-hr morphine consumption was 3.0 mg (95% confidence interval, -9.7 to 15.7). There were no differences regarding the secondary outcomes.

CONCLUSION

A saphenous catheter with a low-dose continuous infusion of ropivacaine, as an adjunct to a sciatic catheter, had no effect on the postoperative analgesia after major ankle surgery when both catheters were inserted along the short axis of the nerves. This trial was registered at ClinicalTrials.gov (NCT01445210).

摘要

目的

连续坐骨神经阻滞用于踝关节大手术后的疼痛管理。隐神经区域的疼痛常常持续存在。我们进行了一项双盲随机安慰剂对照试验,以评估在大腿近端联合腘窝坐骨神经导管及单次隐神经阻滞后,补充隐神经导管对踝关节大手术后疼痛的影响。

方法

50例患者在超声引导下沿神经短轴插入坐骨神经和隐神经连续导管。所有患者均接受初始坐骨神经阻滞,随后进行连续坐骨神经导管输注,并使用罗哌卡因进行初始隐神经阻滞。然后将参与者随机分为术后48小时在隐神经导管中输注罗哌卡因或等渗盐水。主要结局是术后48小时内静脉注射吗啡的总量。次要结局包括临床镇痛、隐神经镇痛、最痛区域及患者满意度。

结果

44例患者纳入分析。干预组48小时吗啡平均(标准差)用量为24.7(21.6)mg,安慰剂组为27.8(20.1)mg(P = 0.63)。48小时吗啡用量的平均差值为3.0 mg(95%置信区间,-9.7至15.7)。次要结局方面无差异。

结论

当两根导管均沿神经短轴插入时,作为坐骨神经导管辅助手段的低剂量连续输注罗哌卡因的隐神经导管,对踝关节大手术后的术后镇痛无影响。本试验已在ClinicalTrials.gov注册(NCT01445210)。

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