99mTc-WBC SPECT/CT 混合显像监测糖尿病足骨髓炎治疗效果。
Hybrid imaging with 99mTc-WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis.
机构信息
Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Int Wound J. 2016 Dec;13(6):1158-1160. doi: 10.1111/iwj.12433. Epub 2015 Apr 8.
This study sought to assess the utility of monitoring response to treatment of diabetic foot osteomyelitis (DFO) with Tc-99m WBC-labelled single photon emission computed tomography (SPECT/CT) imaging. This is a retrospective cohort study of 20 patients with DFO with sequential Tc-99m WBC-labelled SPECT/CT imaging. Radiologic findings of osteomyelitis were evaluated and imaging results were correlated with clinical outcomes subtracted from chart review. Successful treatment of osteomyelitis was defined by wound healing and/or lack of re-admission for bone infection of the same site within 1 year. The sensitivity, specificity, positive predictive value and negative predictive value of SPECT/CT to determine osteomyelitis treatment remission were 90%, 56%, 69% and 83%, respectively. Tc-99m WBC-labelled SPECT/CT imaging may be useful to help determine treatment outcomes for DFO.
本研究旨在评估 Tc-99m WBC 标记单光子发射计算机断层扫描 (SPECT/CT) 成像在监测糖尿病足骨髓炎 (DFO) 治疗反应中的应用价值。这是一项对 20 例 DFO 患者进行的 Tc-99m WBC 标记 SPECT/CT 成像的回顾性队列研究。评估了骨髓炎的放射学发现，并将影像学结果与从图表回顾中减去的临床结果进行了相关性分析。骨髓炎的成功治疗定义为 1 年内同一部位的伤口愈合和/或无骨感染再次入院。SPECT/CT 确定骨髓炎治疗缓解的敏感性、特异性、阳性预测值和阴性预测值分别为 90%、56%、69%和 83%。Tc-99m WBC 标记 SPECT/CT 成像可能有助于确定 DFO 的治疗结果。
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