新型取代的10-甲基-1,2-二氢-1-氧代-1,2,4-三嗪并(4,5-a)吲哚的合成及其抗菌活性
Synthesis and antimicrobial activity of new substituted 10-methyl-1,2-dihydro-1-oxo-1,2,4-triazino(4,5-a)indoles.
作者信息
Rajur S B, Merwade A Y, Basanagoudar L D, Kulkarni P V
机构信息
Department of Chemistry, Kamatak University, Dhawad, India.
出版信息
J Pharm Sci. 1989 Sep;78(9):780-2. doi: 10.1002/jps.2600780917.
PMID:2585276
Abstract
Ten new 4,8-disubstituted 10-methyl-1,2-dihydro-1-oxo-1,2,4-triazino(4,5-a)indoles (5 and 6) were prepared by refluxing various 5-substituted indole-2-carbohydrazides (4) with triethylorthoformate or triethylorthoacetate in dimethylformamide. These derivatives were evaluated for their antimicrobial activity. Some of the title compounds possess fairly potent antimicrobial activity.
摘要
通过在二甲基甲酰胺中将各种5-取代的吲哚-2-碳酰肼（4）与原甲酸三乙酯或原乙酸三乙酯回流，制备了10种新的4,8-二取代的10-甲基-1,2-二氢-1-氧代-1,2,4-三嗪并[4,5-a]吲哚（5和6）。对这些衍生物的抗菌活性进行了评估。一些标题化合物具有相当强的抗菌活性。
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