如何在费希尔-赖特突变选择框架下计算蛋白质编码基因的非同义与同义比率。
How to calculate the non-synonymous to synonymous rate ratio of protein-coding genes under the Fisher-Wright mutation-selection framework.
作者信息
Dos Reis Mario
机构信息
Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
出版信息
Biol Lett. 2015 Apr;11(4):20141031. doi: 10.1098/rsbl.2014.1031.
Abstract
First principles of population genetics are used to obtain formulae relating the non-synonymous to synonymous substitution rate ratio to the selection coefficients acting at codon sites in protein-coding genes. Two theoretical cases are discussed and two examples from real data (a chloroplast gene and a virus polymerase) are given. The formulae give much insight into the dynamics of non-synonymous substitutions and may inform the development of methods to detect adaptive evolution.
摘要
群体遗传学的基本原理被用于推导公式，这些公式将非同义替换率与同义替换率的比值，与作用于蛋白质编码基因密码子位点的选择系数联系起来。文中讨论了两种理论情况，并给出了两个来自实际数据的例子（一个叶绿体基因和一个病毒聚合酶）。这些公式为非同义替换的动态变化提供了深入见解，并可能为检测适应性进化的方法的发展提供参考。
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