九个丙型肝炎病毒4型变体的全长基因组序列，代表一个新的4s亚型和八个未分类谱系。
The full-length genome sequences of nine HCV genotype 4 variants representing a new subtype 4s and eight unclassified lineages.
作者信息
Lu Ling, Xu Yan, Yuan Jie, Li Chunhua, Murphy Donald G
机构信息
Center for Viral Oncology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
School of Life Science, Beijing Institute of Technology, Beijing, China.
出版信息
Virology. 2015 Aug;482:111-6. doi: 10.1016/j.virol.2015.03.038. Epub 2015 Apr 5.
Abstract
We characterized the full-length genomes for nine novel variants of HCV genotype 4 (HCV-4), representing a new subtype 4s and eight unclassified lineages. They were obtained from patients who resided in Canada but all had origins in Africa. An extended maximum clade credibility (MCC) tree was reconstructed after the inclusion of 30 reference sequences. It differentiated 18 assigned subtypes and 10 unclassified lineages within HCV-4. Similar analysis of 102 partial NS5B sequences resulted in another MCC tree that revealed 22 assigned subtypes (4a-4t, 4w, and 4v) and 30 unclassified lineages at the subtype level. Our study shows that HCV-4 is taxonomically complex and it displays high genetic diversity to support an African origin.
摘要
我们对丙型肝炎病毒4型（HCV-4）的九个新型变体的全长基因组进行了特征分析，这些变体代表了一个新的4s亚型和八个未分类的谱系。它们来自居住在加拿大但均起源于非洲的患者。纳入30个参考序列后重建了扩展的最大分支可信度（MCC）树。它区分了HCV-4内的18个指定亚型和10个未分类的谱系。对102个部分NS5B序列进行的类似分析产生了另一个MCC树，该树揭示了22个指定亚型（4a-4t、4w和4v）以及亚型水平上的30个未分类谱系。我们的研究表明，HCV-4在分类学上很复杂，并且显示出高度的遗传多样性以支持其非洲起源。
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