Ahamed M F, Verma P, Lee S, Vega M, Wang D, Kim M, Fuloria M
Division of Neonatal-Perinatal Medicine, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
Division of Neonatology, Alpert Medical School of Brown University, Providence, RI, USA.
J Perinatol. 2015 Sep;35(9):729-34. doi: 10.1038/jp.2015.33. Epub 2015 Apr 9.
To determine whether platelet counts can predict the likelihood of successful closure of patent ductus arteriosus (PDA) with indomethacin.
This was a retrospective cohort study of infants <32 weeks' gestational age (GA) and birth weight <1500 g with PDA. Clinical characteristics between infants who achieved ductal closure with indomethacin and those who failed were compared. Multivariable logistic regression was used to identify predictors of successful ductal closure.
In infants with hemodynamically significant PDA, older GA (odds ratio=1.54; 95% confidence interval: 1.12 to 2.13), male gender (odds ratio=3.02; 95% confidence interval: 1.08 to 8.49) and higher platelet count (odds ratio=1.5; 95% confidence interval: 1.04 to 2.17) prior to indomethacin treatment were associated with successful ductal closure with indomethacin.
Older GA, male gender and higher platelet count at time of treatment of hemodynamically significant PDA are predictors of successful ductal closure with indomethacin.
确定血小板计数是否能够预测吲哚美辛成功闭合动脉导管未闭（PDA）的可能性。
这是一项针对胎龄小于32周、出生体重小于1500g且患有PDA的婴儿的回顾性队列研究。比较了使用吲哚美辛实现导管闭合的婴儿与未实现闭合的婴儿之间的临床特征。采用多变量逻辑回归来确定导管成功闭合的预测因素。
在血流动力学显著的PDA婴儿中，吲哚美辛治疗前胎龄较大（比值比=1.54；95%置信区间：1.12至2.13）、男性（比值比=3.02；95%置信区间：1.08至8.49）以及血小板计数较高（比值比=1.5；95%置信区间：1.04至2.17）与吲哚美辛成功闭合导管相关。
血流动力学显著的PDA治疗时胎龄较大、男性以及血小板计数较高是吲哚美辛成功闭合导管的预测因素。
