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对侧丘脑底核出血所致以腿部为主的偏身投掷症

Hemiballism with leg predominance caused by contralateral subthalamic haemorrhage.

作者信息

Noda Kazuyuki, Hattori Nobutaka, Okuma Yasuyuki

机构信息

Department of Neurology, Juntendo University Shizuoka Hospital, Izunokuni, Japan.

Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Japan.

出版信息

BMJ Case Rep. 2015 Apr 9;2015:bcr2014208525. doi: 10.1136/bcr-2014-208525.

Abstract

Hemiballism is a rare movement disorder characterised by high-amplitude movements of the limbs on one side of the body. Stroke of the contralateral basal ganglia, especially the subthalamic nucleus (STN) is the most common aetiology of acute development of hemiballism. Recently, the pathophysiology of hemiballism has been associated with abnormal firing patterns in the globus pallidus interna, with intermittent firing bursts followed by pauses, during which movements occur. An 87-year-old woman presented with a 5-day history of hemiballism predominantly in her leg. On the basis of her brain MRI findings, she was diagnosed as having vascular hemiballism caused by haemorrhage in the contralateral STN. Treatment with risperidone led to the clinical resolution of her condition. We discuss the distribution of the patient's ballistic movements on the basis of the somatotopic organisation of the STN.

摘要

偏身投掷症是一种罕见的运动障碍,其特征为身体一侧肢体的大幅度运动。对侧基底神经节,尤其是丘脑底核(STN)卒中是偏身投掷症急性发作最常见的病因。最近,偏身投掷症的病理生理学与苍白球内侧部异常放电模式有关,即间歇性放电爆发后出现停顿,在此期间会发生运动。一名87岁女性出现以腿部为主的偏身投掷症5天病史。根据其脑部MRI检查结果,她被诊断为对侧STN出血所致的血管性偏身投掷症。使用利培酮治疗使她的病情得到临床缓解。我们根据STN的躯体定位组织讨论了患者弹道运动的分布情况。

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