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肝硬化:镰状细胞病的一种罕见表现。

Cirrhosis: an unusual presentation of sickle cell disease.

作者信息

Dosi Rupal, Patell Rushad, Jariwala Pooja, Shah Purav, Jasdanwala Sarfaraz

机构信息

Professor, Department of Medicine, Medical College Baroda , Gujarat, India .

Senior Resident, Department of Medicine, Medical College Baroda , Gujarat, India .

出版信息

J Clin Diagn Res. 2015 Feb;9(2):OD03-4. doi: 10.7860/JCDR/2015/8572.5501. Epub 2015 Feb 1.

Abstract

Hepatobiliary complications of sickle cell disease are relatively rare but well recognised in literature. Clinical syndromes range from mild intrahepatic cholestasis and gallstones to life threatening sequestration crisis. Most patients, homozygous for sickle cell anaemia, present before adolescence. We report a case of an adult man with no prior symptoms who presented for the first time with decompensated cirrhosis, which was found to be due to underlying previously unrecognised sickle cell anaemia.

摘要

镰状细胞病的肝胆并发症相对少见,但在文献中已有充分认识。临床综合征范围从轻度肝内胆汁淤积和胆结石到危及生命的脾隔离危象。大多数镰状细胞贫血纯合子患者在青春期前发病。我们报告一例成年男性,此前无任何症状,首次因失代偿性肝硬化就诊,结果发现是由潜在的、先前未被识别的镰状细胞贫血所致。

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本文引用的文献

1
Study of Chronic Hepatopathy in Patients With Sickle Cell Disease.镰状细胞病患者慢性肝病的研究
Gastroenterology Res. 2009 Dec;2(6):338-343. doi: 10.4021/gr2009.12.1327. Epub 2009 Nov 20.
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[The liver in sickle cell anemia].[镰状细胞贫血中的肝脏]
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Sickle cell hepatopathy.镰状细胞性肝病
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Hepatobiliary system in sickle cell disease.镰状细胞病中的肝胆系统。
Gastroenterology. 1986 Jun;90(6):2013-21. doi: 10.1016/0016-5085(86)90276-3.

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