Wood B, Katz V, Bose C, Goolsby R, Kraybill E
Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill.
Obstet Gynecol. 1989 Dec;74(6):889-92.
To provide current clinical information for obstetric decision-making and perinatal management, we present early morbidity and mortality data for extremely premature infants based on obstetric assessment of gestational age. We reviewed the records of 141 live-born infants with birth weights of 1600 g or lower born at a university hospital level III neonatal intensive care unit between January 1986 and April 1988, whose gestational ages estimated by antenatal obstetric evaluation were between 24-29 completed weeks. Neonatal survival to 30 days ranged from 20% at 24 weeks to 94% at 29 weeks. Chronic lung disease was present at 30 days in all infants born at 24 weeks' gestation, decreasing to 13% of infants born at 29 weeks' gestation. Rates of severe intraventricular hemorrhage (grade 3 or 4) ranged from 100% at 24 weeks to 7% at 29 weeks. These data represent a significant increase in survival and a decrease in early morbidity compared with those form similar populations before 1986.
为提供产科决策和围产期管理的当前临床信息，我们基于产科对胎龄的评估，呈现极早早产儿的早期发病率和死亡率数据。我们回顾了1986年1月至1988年4月期间在一所大学医院三级新生儿重症监护病房出生的141例出生体重1600克及以下的活产婴儿的记录，这些婴儿经产前产科评估估计的胎龄在24至29个完整孕周之间。新生儿30天存活率从24周时的20%到29周时的94%不等。所有孕24周出生的婴儿在30天时均患有慢性肺病，而孕29周出生的婴儿中这一比例降至13%。重度脑室内出血（3级或4级）的发生率从24周时的100%降至29周时的7%。与1986年以前类似人群的数据相比，这些数据表明存活率显著提高，早期发病率有所降低。
