抗生素产生放线菌中自身抗性决定因素的结构生物学研究。
Structural biological study of self-resistance determinants in antibiotic-producing actinomycetes.
作者信息
Sugiyama Masanori
机构信息
Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
出版信息
J Antibiot (Tokyo). 2015 Sep;68(9):543-50. doi: 10.1038/ja.2015.32. Epub 2015 Apr 15.
As antibiotics act to inhibit the growth of bacteria, the drugs are useful for treating bacterial infectious diseases. However, microorganisms that produce antibiotics must be protected from the lethal effect of their own antibiotic product. In this review, the fruit of our group's current research on self-protection mechanisms of Streptomyces producing antibiotics that inhibit DNA, protein and bacterial cell wall syntheses will be described.
由于抗生素的作用是抑制细菌生长，因此这些药物可用于治疗细菌感染性疾病。然而，产生抗生素的微生物必须受到保护，以免受到自身抗生素产物的致死作用。在这篇综述中，将描述我们小组目前对产生抑制DNA、蛋白质和细菌细胞壁合成的抗生素的链霉菌自我保护机制的研究成果。
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