Ishikawa Hisashi, Iwamuro Masaya, Okada Hiroyuki, Hori Keisuke, Kita Masahide, Kawano Seiji, Kawahara Yoshiro, Tanaka Takehiro, Kondo Eisei, Yoshino Tadashi, Yamamoto Kazuhide
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.
Intern Med. 2015;54(8):911-6. doi: 10.2169/internalmedicine.54.3784. Epub 2015 Apr 15.
A 36-year-old Japanese woman presented with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the stomach. The gastric lesions only partially improved after eradication therapy for Helicobacter pylori. A fluorescence in situ hybridization analysis revealed no fusion genes of API2-MALT1, although trisomy of chromosome 18 was identified. Radiation therapy was initiated to treat the gastric lymphoma lesions, resulting in complete remission. However, MALT lymphoma recurred in the stomach 16 months later. This case indicates that intensive follow-up is required for MALT lymphoma associated with chromosomal aberrations in order to detect early relapse.
一名36岁的日本女性被诊断患有胃黏膜相关淋巴组织边缘区淋巴瘤（MALT淋巴瘤）。幽门螺杆菌根除治疗后，胃部病变仅部分改善。荧光原位杂交分析显示未发现API2-MALT1融合基因，不过检测到18号染色体三体。开始采用放射治疗胃淋巴瘤病变，结果实现完全缓解。然而，16个月后胃部MALT淋巴瘤复发。该病例表明，对于伴有染色体畸变的MALT淋巴瘤，需要进行密切随访以便早期发现复发。
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