分子印迹聚合物作为塑料抗体模拟物的细胞和组织成像。
Cell and Tissue Imaging with Molecularly Imprinted Polymers as Plastic Antibody Mimics.
机构信息
Sorbonne Universités, Université de Technologie de, Compiègne, CNRS Institute for Enzyme and Cell Engineering, CS30319, 60203, Compiègne, France.
Institute of Pathology Bad Berka, Robert-Koch-Allee 9, 99438, Bad Berka, Germany.
出版信息
Adv Healthc Mater. 2015 Jun 24;4(9):1322-6. doi: 10.1002/adhm.201500145. Epub 2015 Apr 16.
Molecularly imprinted polymers can be used as "plastic antibodies" for cell and tissue imaging, as demonstrated using hyaluronan on cell surfaces as a model target. Fluorescent nanoparticles binding a hyaluronan substructure, glucuronic acid, are used to image fixated and living cells and tissues. Plastic antibodies can be tailored to specific targets and easily labeled, and are physically and chemically stable.
分子印迹聚合物可用作“塑料抗体”进行细胞和组织成像，这已通过以细胞表面透明质酸作为模型靶标进行了证实。荧光纳米颗粒与透明质酸亚结构（葡萄糖醛酸）结合，用于对固定和活细胞及组织进行成像。塑料抗体可针对特定靶标进行定制，并可轻松标记，且具有物理和化学稳定性。
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