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使用边界元建模对简单散射体的DORT方法进行评估。

An assessment of the DORT method on simple scatterers using boundary element modelling.

作者信息

Gélat P, Ter Haar G, Saffari N

机构信息

Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.

出版信息

Phys Med Biol. 2015 May 7;60(9):3715-30. doi: 10.1088/0031-9155/60/9/3715. Epub 2015 Apr 17.

Abstract

The ability to focus through ribs overcomes an important limitation of a high-intensity focused ultrasound (HIFU) system for the treatment of liver tumours. Whilst it is important to generate high enough acoustic pressures at the treatment location for tissue lesioning, it is also paramount to ensure that the resulting ultrasonic dose on the ribs remains below a specified threshold, since ribs both strongly absorb and reflect ultrasound. The DORT (décomposition de l'opérateur de retournement temporel) method has the ability to focus on and through scatterers immersed in an acoustic medium selectively without requiring prior knowledge of their location or geometry. The method requires a multi-element transducer and is implemented via a singular value decomposition of the measured matrix of inter-element transfer functions. The efficacy of a method of focusing through scatterers is often assessed by comparing the specific absorption rate (SAR) at the surface of the scatterer, and at the focal region. The SAR can be obtained from a knowledge of the acoustic pressure magnitude and the acoustic properties of the medium and scatterer. It is well known that measuring acoustic pressures with a calibrated hydrophone at or near a hard surface presents experimental challenges, potentially resulting in increased measurement uncertainties. Hence, the DORT method is usually assessed experimentally by measuring the SAR at locations on the surface of the scatterer after the latter has been removed from the acoustic medium. This is also likely to generate uncertainties in the acoustic pressure measurement. There is therefore a strong case for assessing the efficacy of the DORT method through a validated theoretical model. The boundary element method (BEM) applied to exterior acoustic scattering problems is well-suited for such an assessment. In this study, BEM was used to implement the DORT method theoretically on locally reacting spherical scatterers, and to assess its focusing capability relative to the spherical focusing case, binarised apodisation based on geometric ray tracing and the phase conjugation method.

摘要

穿透肋骨进行聚焦的能力克服了高强度聚焦超声(HIFU)系统在治疗肝脏肿瘤方面的一个重要限制。虽然在治疗部位产生足够高的声压以实现组织损伤很重要,但确保肋骨上产生的超声剂量保持在规定阈值以下也至关重要,因为肋骨对超声有强烈的吸收和反射作用。DORT(时间反转算子分解)方法能够选择性地聚焦于浸没在声学介质中的散射体并穿透它们,而无需事先了解其位置或几何形状。该方法需要一个多元换能器,并通过对测量的阵元间传递函数矩阵进行奇异值分解来实现。一种穿透散射体进行聚焦的方法的有效性通常通过比较散射体表面和焦区的比吸收率(SAR)来评估。SAR可以通过了解声压幅值以及介质和散射体的声学特性来获得。众所周知,在硬表面或其附近使用校准水听器测量声压会带来实验挑战,可能导致测量不确定性增加。因此,DORT方法通常通过在散射体从声学介质中移除后测量其表面位置的SAR来进行实验评估。这也可能在声压测量中产生不确定性。因此,有充分的理由通过经过验证的理论模型来评估DORT方法的有效性。应用于外部声散射问题的边界元法(BEM)非常适合这种评估。在本研究中,使用BEM在理论上对局部反应球形散射体实施DORT方法,并相对于球形聚焦情况、基于几何射线追踪的二值化变迹和相位共轭方法评估其聚焦能力。

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