Mayet A, Duron S, Meynard J-B, Koeck J-L, Deparis X, Migliani R
French Army Centre for Epidemiology and Public Health, Marseille, France.
French Army Centre for Epidemiology and Public Health, Marseille, France.
Public Health. 2015 Jun;129(6):763-8. doi: 10.1016/j.puhe.2015.03.003. Epub 2015 Apr 15.
French military personnel are subject to a compulsory vaccination schedule. The aim of this study was to present the results of surveillance of vaccine adverse events (VAEs) reported from 2011 to 2012 in the French armed forces.
VAEs were surveyed among all French armed forces from 2011 to 2012 by the epidemiological departments of the military health service. For each case, a notification form providing patient and clinical information was provided.
Case definitions were derived from the French drug safety guidelines. Three types of VAE were considered: non-serious, serious and unexpected. Incidence rates were calculated by relating VAEs to the number of vaccine doses delivered.
In total, 161 VAE cases were reported. The overall VAE reporting rate was 24.6 VAEs per 100,000 doses, and the serious VAE rate was 1.3 per 100,000 doses (nine cases). The serious VAEs included two cases of Guillain-Barré syndrome, one case of optic neuritis, one case of a meningeal-like syndrome, one case of rheumatoid purpura, one case of acute asthma and three cases of fainting. The highest rates of VAE were observed with the Bacille Calmette-Guérin vaccine (BCG) (482.3 per 100,000 doses), inactivated diphtheria-tetanus-poliovirus with acellular pertussis vaccine (dTap-IPV) (106.1 per 100,000 doses) and meningococcal quadrivalent glycoconjugate vaccine (MenACWY-CRM) (39.3 per 100,000 doses).
The global rates of VAE observed in 2011 and 2012 confirm the increase that has been observed since 2009 in the French armed forces, which could reflect improved practitioner awareness about VAEs and the use of certain vaccines added to the vaccination schedule recently (dTap-IPV in 2008 and MenACWY-CRM in 2010). VAEs appear to be relatively rare, particularly serious VAEs, which indicates acceptable tolerance of vaccines.
法国军事人员需遵循强制疫苗接种计划。本研究旨在呈现2011年至2012年法国武装部队报告的疫苗不良事件（VAE）监测结果。
2011年至2012年期间，军事卫生服务的流行病学部门对所有法国武装部队中的VAE进行了调查。针对每一例病例，都提供了一份包含患者和临床信息的报告表。
病例定义源自法国药品安全指南。VAE分为三种类型：非严重、严重和意外。通过将VAE与接种疫苗剂量数相关联来计算发病率。
共报告了161例VAE病例。VAE总体报告率为每100,000剂24.6例VAE，严重VAE率为每100,000剂1.3例（9例）。严重VAE包括2例格林-巴利综合征、1例视神经炎、1例类脑膜炎综合征、1例类风湿性紫癜、1例急性哮喘和3例昏厥。VAE发生率最高的是卡介苗（BCG）（每100,000剂482.3例）、无细胞百日咳白喉破伤风脊髓灰质炎灭活疫苗（dTap-IPV）（每100,000剂106.1例）和四价脑膜炎球菌结合疫苗（MenACWY-CRM）（每100,000剂39.3例）。
2011年和2012年观察到的VAE总体发生率证实了自2009年以来法国武装部队中VAE发生率的上升，这可能反映出从业者对VAE的认识有所提高，以及最近疫苗接种计划中新增了某些疫苗（2008年的dTap-IPV和2010年的MenACWY-CRM）。VAE似乎相对罕见，尤其是严重VAE，这表明疫苗的耐受性是可接受的。
