双氯芬酸可导致大鼠近端结肠出现吻合口漏，但不会导致远端结肠出现吻合口漏。
Diclofenac causes anastomotic leakage in the proximal colon but not in the distal colon of the rat.
作者信息
Yauw Simon T K, Lomme Roger M L M, van der Vijver Rozemarijn J, Hendriks Thijs, van Laarhoven Kees J H M, van Goor Harry
机构信息
Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
出版信息
Am J Surg. 2015 Aug;210(2):382-8. doi: 10.1016/j.amjsurg.2014.10.028. Epub 2015 Mar 25.
BACKGROUND
Nonsteroidal anti-inflammatory drugs have been associated with anastomotic leakage. It was studied if diclofenac affects anastomoses differently depending on the location in the gut.
METHODS
Ninety-five rats were randomized to 6 groups with an anastomosis in either ileum (IL), proximal colon (PC), or distal colon (DC). Groups IL+ (n = 10), PC+ (n = 30), and DC+ (n = 10) received diclofenac (3 mg/kg/day) from day 0 until sacrifice on day 3. Group PC- (n = 15) did not receive diclofenac. Groups PC1+ and PC2+ (n = 15 each) were given diclofenac from day 1 to 4 and from day 2 to 5.
RESULTS
Leak rates were 10/10 in group IL+, 22/30 in PC+, 1/10 in DC+, and 1/15 in PC-. Delayed administration of diclofenac by 1 or 2 days (6/15, P = .05) resulted in reduced leakage rates. Mechanical strength results corresponded with leak rates.
CONCLUSIONS
Diclofenac causes leakage of anastomoses in rat IL and PC, but not in the DC. This suggests a role for the ileal and proximal colonic content in diclofenac-induced leakage.
背景
非甾体类抗炎药与吻合口漏有关。研究了双氯芬酸对肠道不同部位吻合口的影响是否不同。
方法
95只大鼠被随机分为6组，分别在回肠（IL）、近端结肠（PC）或远端结肠（DC）进行吻合。IL+组（n = 10）、PC+组（n = 30）和DC+组（n = 10）从第0天至第3天处死前接受双氯芬酸（3毫克/千克/天）。PC-组（n = 15）未接受双氯芬酸。PC1+组和PC2+组（每组n = 15）分别在第1天至第4天和第2天至第5天给予双氯芬酸。
结果
IL+组的漏出率为10/10，PC+组为22/30，DC+组为1/10，PC-组为1/15。双氯芬酸延迟1天或2天给药（6/15，P = 0.05）导致漏出率降低。机械强度结果与漏出率相符。
结论
双氯芬酸可导致大鼠回肠和近端结肠吻合口漏，但不会导致远端结肠吻合口漏。这表明回肠和近端结肠内容物在双氯芬酸诱导的漏出中起作用。
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