Christ Martin, von Auenmueller Katharina Isabel, Liebeton Jeanette, Grett Martin, Dierschke Wolfgang, Noelke Jan Peter, Breker Irini Maria, Trappe Hans-Joachim
Department of Cardiology and Angiology, Marienhospital Herne, Ruhr - University Bochum, Germany.
Int J Med Sci. 2015 Mar 28;12(4):306-11. doi: 10.7150/ijms.11343. eCollection 2015.
Despite a generally broad use of vascular closure devices (VCDs), it remains unclear whether they can also be used in victims from out-of-hospital cardiac arrest (OHCA) treated with mild therapeutic hypothermia (MTH).
All victims from OHCA who received immediate coronary angiography after OHCA between January 1(st) 2008 and December 31(st) 2013 were included in this study. The operator decided to either use a VCD (Angio-Seal™) or manual compression for femoral artery puncture. The decision to induce MTH was based on the clinical circumstances.
76 patients were included in this study, 46 (60.5%) men and 30 (39.5%) women with a mean age of 64.2 ± 12.8 years. VCDs were used in 26 patients (34.2%), and 48 patients (63.2%) were treated with MTH. While there were significantly more overall vascular complications in the group of patients treated with MTH (12.5% versus 0.0%; p=0.05), vascular complications were similar between patients with VCD or manual compression, regardless of whether or not they were treated with MTH.
In our study, the overall rate of vascular complications related to coronary angiography was higher in patients treated with mild therapeutic hypothermia, but was not affected by the application of a vascular closure device. Therefore, our data suggest that the use of VCDs in victims from OHCA might be feasible and safe in patients treated with MTH as well, at least if the decision to use them is individually carefully determined.
尽管血管闭合装置(VCDs)已得到广泛应用,但对于院外心脏骤停(OHCA)且接受轻度治疗性低温(MTH)的患者,能否使用该装置仍不明确。
本研究纳入了2008年1月1日至2013年12月31日期间OHCA后立即接受冠状动脉造影的所有患者。术者决定采用VCD(Angio-Seal™)或手动压迫进行股动脉穿刺。是否诱导MTH取决于临床情况。
本研究共纳入76例患者,其中男性46例(60.5%),女性30例(39.5%),平均年龄64.2±12.8岁。26例患者(34.2%)使用了VCD,48例患者(63.2%)接受了MTH治疗。虽然接受MTH治疗的患者总体血管并发症明显更多(12.5%对0.0%;p=0.05),但无论是否接受MTH治疗,使用VCD或手动压迫的患者血管并发症相似。
在我们的研究中,接受轻度治疗性低温的患者与冠状动脉造影相关的总体血管并发症发生率较高,但不受血管闭合装置应用的影响。因此,我们的数据表明,在接受MTH治疗的OHCA患者中使用VCDs可能也是可行且安全的,至少如果使用的决定是经过仔细个体化确定的话。