[Congenital bilateral absence of vas deferens: From diagnosis to assisted reproductive techniques - the experience of three centers]. - Suppr

[Congenital bilateral absence of vas deferens: From diagnosis to assisted reproductive techniques - the experience of three centers].

作者信息

Beauvillard D, Perrin A, Drapier H, Ravel C, Fréour T, Férec C, De Braekeleer M, Amice V

机构信息

Faculté de médecine et des sciences de la santé, université de Brest, 22, rue Camille-Desmoulins, 29200 Brest, France; Service de cytogénétique et de biologie de la reproduction, hôpital Morvan, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France; Institut national de la santé et de la recherche médicale (Inserm), U1078, 46, rue Félix-Le-Dantec, CS51819 Brest cedex 2, France.

出版信息

Gynecol Obstet Fertil. 2015 May;43(5):367-74. doi: 10.1016/j.gyobfe.2015.03.009. Epub 2015 Apr 17.

DOI:10.1016/j.gyobfe.2015.03.009

PMID:25899114

Abstract

OBJECTIVES

To review the management with assisted reproductive technologies (ART) of men with congenital bilateral absence of vas deferens (CBAVD), associated with cystic fibrosis or not, after surgical retrieval [epididymal aspiration (MESA) or testicular biopsy (TESE)].

METHODS

Multicenter retrospective study made of 2 groups: CBAVD and cystic fibrosis (CF) or CBAVD only (CF-RD). Two centers performed MESA (Brest and Nantes) and one TESE (Rennes). Sperm numeration, motility, vitality, morphology and nuclear maturity were measured in both centers performing MESA. Fertilization rate (TF) and cumulated progressive pregnancy rate by retrieved oocyte (TGC) were compared between centers following ART.

RESULTS

Ninety patients underwent surgical retrieval between January 1996 and March 2013, 30 in the CF group and 60 in the CF-RD group. Semen parameters were comparable between groups and centers. Fifty-eight (22 in the CF group and 36 in the CF-RD group) patients received ART between April 1996 and October 2014. TF was 50% and 52% and TGC 26% and 32% in the CF group and CF-RD groups, respectively. The results did not differ between groups but TGC was higher in Rennes than in the other two centers.

CONCLUSION

Both semen parameters and ART results are comparable and similar to those reported in the literature. As shown by the results obtained in Rennes, TESE seems to be more effective.

摘要