儿童系统性红斑狼疮中的无血管性坏死：一篇简短报告及文献综述
Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature.
作者信息
Gurion Reut, Tangpricha Vin, Yow Eric, Schanberg Laura E, McComsey Grace A, Robinson Angela Byun
机构信息
Division of Pediatric Infectious Diseases, Rheumatology and Global Health, Department of Pediatrics, Rainbow Babies and Children's Hospital/Case Medical Center, Cleveland, OH, USA.
Division of Endocrinology, Metabolism & Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
出版信息
Pediatr Rheumatol Online J. 2015 Apr 23;13:13. doi: 10.1186/s12969-015-0008-x.
UNLABELLED
Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities.
TRIAL REGISTRATION
ClinicalTrials.gov identifier: NCT00065806.
未标注
无血管性坏死（AVN）发生于多种慢性疾病，包括系统性红斑狼疮（SLE），但也可发生于健康儿童。有多种理论解释AVN发生的原因及机制，但确切机制尚未阐明。儿科狼疮患者中的AVN研究不足。儿科狼疮性动脉粥样硬化预防（APPLE）试验为进行探索性分析提供了一个绝佳场所，以评估AVN与人口统计学、SLE疾病活动及维生素D缺乏之间的关联。在此，我们给出一份简短报告描述我们的发现，并回顾关于SLE及其他疾病中AVN的文献。
试验注册
ClinicalTrials.gov标识符：NCT00065806。
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